Multichannel Deep Brain Stimulation System

描述（由申请人提供）：提交本提案以响应RFA-NS-02-004（安全有效脑深部电刺激技术开发）。我们已经解决了研究目标#3，“开发可充电和/或具有更宽刺激速率、刺激电流、脉冲宽度、脉冲波形范围的刺激器，并允许从电极记录和刺激。" 1)我们将开发一种用于脑深部电刺激的刺激器，该刺激器可充电，并且具有比任何其他可用系统更宽的刺激速率、刺激电流和脉冲宽度范围。该开发将包括外部充电器和程控刺激器所需的工具。 2)我们将开发一种具有上述功能的脑深部电刺激刺激器，该刺激器可以安装在头骨中，从而避免了将电极导线穿过颈部的需要。.这允许DBS系统的植入，而不需要全身麻醉和伴随的风险，并且这通过避免电极导线穿过高度移动的颈部区域来降低电极导线断裂或断裂的风险。 3)我们将开发一种用于深部脑刺激的刺激器，包括感知神经元的电活动。该系统可以使用刺激电极进行感测，或者可以包括与刺激电极阵列集成的单独的记录电极。该系统还可以配置有用于单独记录引线的连接器，该单独记录引线可以放置在远离刺激区域的大脑部分中。 4)我们计划将上述刺激器提供给NIH脑深部电刺激（DBS）联盟的成员以及其他DBS研究人员进行研究和测试。

DESCRIPTION (provided by applicant): This proposal is submitted in response to RFA-NS-02-004 (Technology development for safe and effective deep brain stimulation). We have addressed Research Objective #3, "The development of stimulators that are rechargeable and/or that have a wider range of stimulation rates, stimulation currents, pulse widths, pulse waveforms, and that permit recording from electrodes as well as stimulation." 1) We will develop a stimulator for deep brain stimulation that is rechargeable and that has a wider range of stimulation rates, stimulation currents, and pulse widths than any other available system. This development will include the external recharger and the tools required to program the stimulator. 2) We will develop a stimulator for deep brain stimulation with the above capabilities that can be mounted in the skull, thereby obviating the need to tunnel a lead through the neck. . This allows implantation of the DBS system without the need and the attendant risks of general anesthesia, and this reduces the risk of lead fracture or breakage by avoiding passage of the lead through the highly mobile neck area. 3) We will develop a stimulator for deep brain stimulation that includes sensing of the electrical activity of neurons. This system may use the stimulation electrodes for sensing or may incorporate separate recording electrodes integrated with the stimulation electrode array. The system may also be configured with a connector for a separate recording lead that may be place in a part of the brain that is relatively far removed from the area of stimulation. 4) We plan to make the above stimulators available to members of the NIH Deep Brain Stimulation (DBS) consortium as well as other DBS researchers for research and testing.