Regulation of the Warburg Effect in Cancer

描述(由申请人提供) 摘要：癌细胞的代谢与正常细胞的代谢不同。这种改变的肿瘤细胞代谢被称为Warburg效应(或有氧糖酵解)，其特征是即使在氧气存在的情况下，乳酸生成增加，氧化磷酸化减少。尽管这一观察最早是在75年前进行的，但癌细胞如何建立这种改变的新陈代谢，以及它对肿瘤发生是否重要，目前仍不清楚。我们的研究旨在确定肿瘤细胞在癌症中建立和维持Warburg效应的分子机制，明确Warburg效应是否对肿瘤生长是必要的，并在体内寻找负责维持Warburg效应的新的抗癌药物靶点。这项研究将确定靶向癌症代谢是否是癌症治疗的可行方法，并将更好地确定代谢对肿瘤生长的作用。 公共卫生相关性：这项拟议的研究将调查在癌细胞中发现的新陈代谢改变的原因。它还将测试针对这种改变的新陈代谢是否是癌症治疗的可行策略。

DESCRIPTION (Provided by the applicant) Abstract: The metabolism of cancer cells is different from that of their normal cell counterparts. Known as the Warburg effect (or aerobic glycolysis), this altered tumor cell metabolism is characterized by enhanced lactate production with reduced oxidative phosphorylation even in the presence of oxygen. Although this observation was first made over 75 years ago, how cancer cells establish this altered metabolism and whether it is important for tumorigenesis remains unknown. Our research aims to determine the molecular mechanisms by which tumor cells establish and maintain the Warburg effect in cancer, to definitively address whether the Warburg effect is necessary for tumor growth, and to identify novel cancer drug targets responsible for maintenance of the Warburg effect in vivo. This study will determine whether targeting cancer metabolism is a viable approach for cancer therapy and will better define the role of metabolism for tumor growth. Public Health Relevance: This proposed research will investigate causes of the altered metabolism found in cancer cells. It will also test whether targeting this altered metabolism is a viable strategy for cancer therapeutics.