Neural signatures of disease spread and evolution in motor neurodegenerative syndromes

运动神经元疾病（MND），也称为肌萎缩侧索硬化症（ALS），由于缺乏对运动神经元疾病（MND）引起的早期变化的了解，阻碍了早期诊断和治疗干预。拟议的项目旨在利用有针对性的神经心理学评估和先进的多模态神经影像学来跟踪疾病进展，全面评估具有与MND相关的已知基因突变的症状前携带者在疾病发作前的神经系统变化。

A lack of understanding of the earliest changes brought on by motor neurone disease (MND), otherwise known as amyotrophic lateral sclerosis (ALS), prevents early diagnosis and therapeutic intervention. The proposed project aims to comprehensively characterise neurological changes prior to disease onset in pre-symptomatic carriers with a known genetic mutation linked to MND using targeted neuropsychological assessments and advanced multi-modal neuroimaging to track disease progression.