Health Impacts of Toxic Combustion By-Products

该计划解决了燃烧产生的有机污染物和颗粒之间的协同作用，这些污染物和颗粒增加了它们的化学和生物活性。项目目标包括：1)了解人与人之间的关系。来源、形成机制、排放物的性质；生物有效性；和生物活性有毒燃烧副产品；2)改进的、对健康有影响的工程设计的热处理技术；3)可以作出基于FISK的智能决策 超级基金废物的现场处理与非现场处理以及热处理与非热处理选项。 我们的研究将集中在四类污染物的来源和对健康的影响：1)燃烧产生的超细颗粒物(UFP)，2)持久性自由基(PFRs)，3)氯代烃(CHQ)，和4)。溴代烃(BHG)。燃烧产生的UFP或直径小于？0i1：rNicrcons-.的“纳米颗粒”与空气中PM2.5.1的有害物质对健康的影响有关 而且，六六六一直是超级基金网站最值得关注的化学品之一，它们的热降解已知会产生有毒副产品，包括多氯化和溴化的二苯并-二恶英和二苯并呋喃。我们将特别关注CHCs和BHCs在UFP上的化学吸附作用，以形成表面稳定的PFR，它可以在暴露的个人中产生氧化应激，以及BE 新污染物形成的关键中间体。全氟化碳是一种新的污染物，可能导致观察到的UFP对健康的一些影响，过去三年来一直是我们研究团队主要成员进行的独特研究的主题。在这项提案中，除了环境政策科学家外，一个由生物医学、生物、化学和工程研究人员组成的多学科团队将研究有毒物质、空气污染物和燃烧/热能对人体健康的影响。 危险废物的处理。这个项目是真正跨学科的，因为它有一个明确的目标来确定这种联系的性质，因此将要求每一组研究人员超越他们传统上狭窄的研究脉络，整合他们的理解。该计划由三个生物医学项目、三个非生物医学项目、四个研究支持核心、一个行政核心、一个研究翻译核心、一个社区推广核心和一个培训核心组成。

This program addresses the synergistic interactions of combustion-generated organic pollutants and particles that increase their chemical and, biological activity. Program goals include: 1) understand the relationships'.between'the. origin, mechanisms of formation, nature of emissions; biological availability; and biological activitybttoxic combustion by-products such that; 2) improved, health effects-engineered, thermal treatment technologies can be developed; and 3) intelligent fisk^based decisions can be made concerning on-site versus offsite treatment and thermal versus non-thermal treatment options of Superfund Wastes. Our research will focus on the origin and health impacts of four classes of pollutants: 1) combustiongenerated ultra-fine particles (UFPs), 2) persistent free radicals (PFRs), 3) chlorinated hydrocarbons (CHQs), and 4). brorninated hydrocarbons (BHGs). Combustion generates UFPs or "nanoparticies" with diameters less than?0i1:rnicrcons-.whieh;have7been linked to:the'health impacts, of airborne PM2.5.1 OHCs and;BHCs consistently rankamong the most significant chemicals of concern at Superfund sites, and their thermal degradation is known to create toxic by-products including polychlorinated and brorninated dibenzcp-dioxins and dibenzofurans. We will specifically focus on the role of chemisorption.of CHCs and BHCs on UFPs to form surface-stabilized PFRs that can generate oxidative stress in exposed individuals as well as be key intermediates in the formation of new pollutants. PFRs are a new class of pollutants that may be responsible for some of the observed health impacts of UFPs and has been the subject of unique research by key members of our research team for the past 3 years. In this proposal, a multidisciplinary team of biomedical, biological, chemical, and engineering researchers in addition to environmental policy scientists will address the lihksvbetween human health impacts of toxic; air pollutants and combustion/thermal processing of hazardous wastes., this program is truly interdisciplinary as!it has a specific goal of establishing the nature of this link, and as such will require each group of researchers to go beyond their traditionally narrow veins of research and to integrate their understanding. The program consists of: three biomedical projects, three non-biomedical projects, four research support cores, an administrative core, a research translation core, a community outreach core, and a training core.