Bioactive Compounds from the Biodiversity of Vietnam and Laos

描述（由申请人提供）：该拟定ICBG（伊利诺伊大学芝加哥分校/UIC的中越ICBG“生物活性化合物”）是UIC的越南-老挝ICBG第二阶段“越南和老挝生物多样性研究”的修改延续。“目前申请的主旨和长期目标是发现生物活性化合物，主要来自中国和越南的生物多样性来源材料，作为药物开发的候选物。该申请的具体目标涉及以下长期成就：（i）从中国西南部的微生物多样性、Nui Chua国家公园NCNP（越南）的微生物和海洋多样性、南中国海的海洋生物多样性和UIC-ICBG第二阶段遗产植物提取物中发现用于治疗艾滋病毒/艾滋病、癌症、结核病和疟疾的新药;（ii）发现新的纤维素降解和生物燃料生产微生物菌株;（iii）促进新的知识和加强对NCNP海洋和陆地生物多样性的保护工作; ㈣增强北卡罗来纳州沿海社区的能力，通过珊瑚礁恢复改善其生活条件，通过努力增加该地区的生态旅游，促进能力建设和加强中国和越南合作机构的基础设施。为了实现上述目标，六个完全一体化的联合计划/行动计划将协同工作：（中国西南部和越南）; AP 2-Nui Chua国家公园（越南）的生物多样性资源材料采集、保护和经济发展; AP 3-微生物生物燃料勘探（越南，中国西南部）; AP 4-中美优先疾病：癌症和艾滋病毒/艾滋病; AP 5-药物发现化学; AP 6-越南优先疾病：结核病和疟疾。这六个AP将在位于UIC的集团协调下运作。该修订后的第三阶段中越ICBG“生物活性化合物”的操作和功能将受第三阶段协议备忘录（MOA）的约束和指导，该备忘录是第二阶段MOA的修订版II。公共卫生相关性：癌症和艾滋病毒/艾滋病是美国、中国和全球的优先疾病，而结核病和疟疾是越南和其他发展中国家的严重和优先疾病。通过ICBG发现和开发用于治疗这些疾病的临床有用药物，将通过减轻人类痛苦和改善人类福利，为公共卫生做出重大贡献。

DESCRIPTION (provided by applicant): This proposed ICBG (University of Illinois at Chicago/UIC-based China-Vietnam ICBG "Bioactive Compounds") is a modified continuation of the UlC-based Vietnam-Laos ICBG Phase II "Studies on Biodiversity of Vietnam and Laos." The thrust and long-term goal of the current application is the discovery of bioactive compounds, primarily from the biodiversity source materials originated from China and Vietnam, as candidates for drug development. The specific aims of the application address long-term achievements as follows: (i) discovery of new drugs for therapies against HIV/AIDS, cancer, tuberculosis, and malaria from microbial diversity of Southwestern China, microbial and marine diversity of Nui Chua National Park NCNP (Vietnam), marine biodiversity of South China Sea, and UIC-ICBG Phase II legacy plant extracts; (ii) discovery of new cellulose-degrading and biofuel-producing microbial strains; (iii) advancing new knowledge and strengthening conservation efforts on marine and terrestrial biodiversity in NCNP; (iv) empowering coastal communities of NCNP to improve their living conditions through coral reef restoration, and through effort to increase eco-tourism to the area, and promoting capacity building and strengthening of the infrastructure of the partner institutions in China and Vietnam. To achieve the above stated aims, six fully integrated Associate Programs/AP will work in synergy: AP1 - Microbial Biodiversity (SW China and Vietnam); AP2 - Biodiversity Source Materials Acquisition, Conservation, and Economic Development in Nui Chua National Park (Vietnam); AP3 - Microbial Biofuel Exploration (Vietnam, SW China); AP4 - US-China Priority Diseases: Cancer and HIV/AIDS; AP5 - Drug Discovery Chemistry; AP6 - Vietnam-Priority Diseases: Tuberculosis and Malaria. These six APs will operate under the coordination of the GROUP PROGRAM based at UIC. The operation and functioning of this modified Phase III China-Vietnam ICBG "Bioactive Compounds" will be subject to and guided by a Phase III Memorandum of Agreement (MOA), which is Amendment II of the Phase II MOA. PUBLIC HEALTH RELEVANCE: Cancer and HIV/AIDS are priority diseases in the United States, China, and globally, while tuberculosis and malaria are serious and priority diseases in Vietnam, and in other developing countries. Discovery and development by this ICBG of clinically useful agents for therapies against these diseases will significantly contribute to public health through the alleviation of human's sufferings and improvement of human welfare.