Clinical-In Vivo Functional Onco-Imaging (IVFOI)

核心006 -临床-项目总结/摘要-体内功能性肿瘤成像（IVFOI） 体内功能性肿瘤成像（IVFOI）共享资源的目的是增强和支持基本的 和临床癌症研究人员，为他们提供必要的专业知识，成像仪器， 图像分析技术。当前可用的系统包括三种MRI扫描仪（3 T-人体，4 T-人体 和动物，和7 T-动物）和几个尖端的多模态成像系统的小动物 成像：a）组合的MRI-扩散光学断层扫描（DOT）系统，B）组合的MRI-SPECT（单次 光子发射计算机断层扫描）系统，和c）混合X射线显微CT-光学断层扫描系统。 4 T MRI扫描仪为开发新的成像方法以及 第二模态例如DOT的集成以形成组合系统。除了光学成像， 建立了世界上第一个MR兼容SPECT系统的小动物成像。除此之外，我们还有 开发了一种与微型CT集成的三维荧光和生物发光断层扫描系统。这些多- 模态成像系统在这一点上可用于一般用途。除了这个小动物成像 仪器，我们一直致力于几个新的多模态系统的乳腺癌成像，磁共振- 光学和磁共振核成像，我们正计划使他们提供给癌症坎特成员， 接下来的几年这些系统将支持CFCCC成员在设计创新成像方面的各种需求 这些组件纳入他们的研究，提供互补的解剖和功能信息。此外，本发明还 我们的共享资源还支持转化临床研究，具有精确的方案执行和高质量的 标准质量控制。例如，我们一直支持收集900多个乳腺MRI 研究采用统一的方案，因此收集了一个大型数据库。在下一个周期，我们将 继续支持这些临床研究，并支持使用多学科的转化临床研究， 我们的产品组合中的模态成像系统，例如评估组合的诊断性能 用于乳腺癌的MRI光学和MR核成像系统。 总的来说，IVFOI共享资源为CFCCC成员提供了随时访问最先进的 技术、实验设计和成像方案咨询、图像采集和数据 分析，以及各个项目之间的协调。通过分享成像和分析 协议，我们可以整合从不同项目获得的各种信息，以促进未来的合作 在CFCCC成员之间，将基础科学家和临床研究人员聚集在一起， 进行临床转化研究。

Core 006 - Clinical - Project Summary/Abstract - In Vivo Functional Onco-Imaging (IVFOI) The aim of the In-Vivo Functional Onco-Imaging (IVFOI) Shared Resource is to enhance and support basic and clinical cancer researchers by providing them with the necessary expertise, imaging instrumentation, and image analysis techniques. The current available systems include three MRI scanners (3T- human, 4T- human and animal, and 7T- animal) and several cutting-edge multi-modality imaging systems for small animal imaging: a) combined MRI- Diffuse Optical Tomography (DOT) system, b) combined MRI-SPECT (Single Photon Emission Computed Tomography) system, and c) hybrid X-ray microCT-Optical Tomography system. The 4T MRI scanner provides an open architecture for development of new imaging methods, as well as for integration of a second modality such as DOT to form a combined system. Besides optical imaging, we have built world's first MR compatible SPECT system for small animal imaging. In addition to this we have developed a 3-D fluorescence & bioluminescence tomography system integrated with a micro CT. These multi- modality imaging systems are available for general use at this point. Beyond this small animal imaging instrumentation, we have been working on several new multi-modality systems for breast cancer imaging, MR- Optical and MR-Nuclear Imaging, and we are planning to make them available for Cancer Canter members in the next years. These systems will support various needs of CFCCC members in designing innovative imaging components into their studies, providing complementary anatomical and functional information. Additionally, our shared resource also supports translational clinical studies, with a precise protocol execution and a high standard quality control. For example, we have been supporting the collection of more than 900 breast MRI studies with unified protocols, and as such a large database has been collected. In the next cycle we will continue to support such clinical studies, and also to support translational clinical research using the multi- modality imaging systems in our portfolio, such as to evaluate the diagnostic performance of the combined MRI-Optical and MR-Nuclear imaging systems for breast cancer. Overall, the IVFOI Shared Resource provides CFCCC Members with ready access to state-of-the-art technologies, consultation for design of experiments and imaging protocols, and image acquisition and data analysis, as well as coordination among individual projects. Through the sharing of imaging and analysis protocols, we can integrate various information obtained from different projects to facilitate future collaborations between CFCCC members and to bring together basic scientists and clinical researchers to design and conduct clinical translational studies.