HIV-associated Tuberculosis Training Program (HATTP)

摘要 我们将在开普敦大学建立一个Fogarty艾滋病相关结核病培训项目 (UCT)与约翰霍普金斯大学（JHU）和范德比尔特大学医学中心（VUMC）合作 利用这些机构之间现有的研究合作，提供艾滋病毒相关结核病（HIV-TB） 在UCT接受培训。该计划将满足以下需求：更多的临床科学家/研究人员需要 接受培训，在UCT培养下一代艾滋病毒/结核病科学领导人;迫切需要 加快UCT研究人员人口构成的转变，以纠正 在高端分析方法方面有具体的培训要求， 将UCT的产能提升到新的水平。选定了五个重点培训领域：1）临床流行病学 和生物统计学，包括艾滋病毒-结核病诊断研究; 2）艾滋病毒-结核病的先进流行病学和建模， 结核病流行和干预措施; 3）艾滋病毒和结核病药物的临床药代动力学及其相互作用， 包括药物基因组学和遗传流行病学; 4）免疫发病机制的转化研究 艾滋病与结核病合并感染和疾病的研究; 5）超敏反应的流行病学和发病机制研究 对艾滋病药物的反应。我们将提供11个博士研究金（2个给医学生; 5个给医生; 4个 基础科学家）和4个博士后研究金，分布在五个重点领域，共同指导 作为长期培训。在这15个奖学金中，10个将针对新兴国家， 黑人艾滋病研究者我们将提供以下中期培训机会：5-10个月的培训 4名学员在美国机构学习实验室或分析方法;参加JHU 流行病学和生物统计学暑期研究生院，供6名受训人员参加;网上流行病学和 生物统计学课程。短期培训将包括短期课程的主题，包括赠款写作， 管理，职业指导，观察流行病学，生物统计学和遗传流行病学。一种新型 我们计划的一个方面是为五年级医学生开设“进入艾滋病毒-结核病研究”课程， 持续联系并参与HIV-TB药物警戒网络，目的是 大多数有才华和承诺的学生回到UCT发展艾滋病毒结核病研究事业。这个学生 该计划将强调黑人学生的机会。将有两个月的研究研讨会和一个 年度研讨会。该计划将由Meintjes博士（PI）领导，协调委员会由九名成员组成 代表所有伙伴机构。培训咨询委员会将提供监督 由Heimburger博士（VUMC）和其他四名成员（Mayosi，Mizrahi，Young和Beyrer博士）担任主席。 年度结构化评估过程将评估个人发展和总体计划产出， 结果和表现，并将涉及书面报告和反馈，从TAC，PI和 协调委员会将使用以改进该方案。

ABSTRACT We will establish a Fogarty HIV-associated Tuberculosis Training Program at the University of Cape Town (UCT) in partnership with Johns Hopkins University (JHU) and Vanderbilt University Medical Center (VUMC) building on existing research collaborations between these institutions to provide HIV-associated TB (HIV-TB) training at UCT. The Program will address the following needs: more clinician scientists/researchers need to be trained to develop the next generation of scientific leaders in HIV-TB at UCT; there is an urgent need to accelerate transformation of the demographic composition of researchers at UCT to redress disparities that persist from apartheid; and there are specific training requirements in high-end analytical methods needed to lift UCT's capacity to the next level. Five focus areas for training have been chosen: 1) Clinical epidemiology and biostatistics, including HIV-TB diagnostic research; 2) Advanced epidemiology and modelling of the HIV- TB epidemic and interventions; 3) Clinical pharmacokinetics of HIV and TB drugs and their interactions, including pharmacogenomics and genetic epidemiology; 4) Translational research of the immunopathogenesis of HIV-TB co-infection and disease; and 5) Epidemiological and pathogenesis research of hypersensitivity reactions to HIV-TB drugs. We will provide 11 PhD fellowships (2 to medical students; 5 to medical doctors; 4 to basic scientists) and 4 post-doctoral fellowships, spread across the five focus areas, with shared mentorship from the partner institutions as long-term training. Of these 15 fellowships, 10 will be targeted to emerging black HIV-TB researchers. We will offer the following medium-term training opportunities: 5-10 month training periods at US institutions to learn a laboratory or analytical method for 4 trainees; attendance at the JHU Graduate Summer Institute of Epidemiology and Biostatistics for 6 trainees; and web-based epidemiology and biostatistics courses. Short-term training will include short courses on topics including grant writing and management, career coaching, observational epidemiology, biostatistics, and genetic epidemiology. A novel aspect of our Program will be an “Entry into HIV-TB research” course for 5th year medical students followed by ongoing contact and participation in an HIV-TB Pharmacovigilance Network, with the objective of having the most talented and committed students return to UCT to develop careers in HIV-TB research. This student program will emphasize opportunities for black students. There will be two-monthly research seminars and an annual symposium. The Program will be led by Dr. Meintjes (PI) with a nine-member Coordinating Committee representing all partner institutions. Oversight will be provided by a Training Advisory Committee (TAC) chaired by Dr. Heimburger (VUMC) and with four other members (Drs. Mayosi, Mizrahi, Young, and Beyrer). An annual structured evaluation process will assess individual development and overall Program outputs, outcomes and performance, and will involve a written report to and feedback from the TAC, which the PI and Coordinating Committee will use to improve the Program.