Pediatric Critical Care Research Network at Children's Hospital of Philadelphia

 描述(由申请人提供)：儿科重症监护医学已经发展成为一门基于成人和动物研究的外推数据的临床艺术。尤尼斯·肯尼迪·施莱弗国家儿童健康与人类发展研究所(NICHD)开发了一个合作的儿科重症监护研究网络(CPCCRN)，通过创新的、尖端的、多学科的临床研究，将儿科重症监护从基于病理生理学的艺术转变为基于证据的科学实践。费城儿童医院(CHOP)在2009年至2014年期间一直是CPCCRN临床网站中的佼佼者，由Berg博士和Zipper博士领导。CHOP继续成为CPCCRN网站的建议有三个组成部分：#1：证明CHOP有能力成为一个出色的CPCCRN临床网站。CHOP是一家排名最高的儿童医院，拥有全国最大的儿科研究项目之一：每年联邦拨款总额为1.38亿美元，年度预算为3.29亿美元。CHOP拥有全国最大的儿科保健系统，也是全国最大的儿童医院之一，拥有500张床位。CHOP的重症监护医学计划是美国最大的项目之一，拥有55个PICU床位、32个CICU床位和每年4200名入院者，为临床研究提供了一个庞大而多样化的患者基础。CHOP重症监护医学拥有9名研究人员，联邦研究基金提供=20%的工资支持，过去3年发表了180篇同行评议的研究论文，以及国家认可的儿科重症监护临床研究计划。#2：证明CHOP一直是CPCCRN临床网站(2009-2014)的杰出代表。从2009年到2014年，CHOP一直是CPCCRN研究的领先招生网站。伯格博士领导了四项CPCCRN CPR研究；Zipper博士领导了两项CPCCRN药理学研究；Dilbert女士(CHOP CPCCRN研究协调员)领导了CPCCRN研究协调员教育和管理项目。具体目标3：提出一项具有变革性的研究“概念提案”，突出我们在网络中开发和设计高影响力合作方案的能力和优势：一种提高需要心肺复苏(CPR)儿童存活率的救命办法。费城儿童医院是CPCCRN的理想临床网站，其基础是：1)杰出的资源、机构承诺、项目、师资、生产力和未来机会；2)CHOP在2009-2014年间作为CPCCRN临床网站的出色表现；3)令人兴奋的“概念提案”，展示了我们作为CPCCRN领导者的能力。

 DESCRIPTION (provided by applicant): Pediatric Critical Care Medicine has developed as a clinical art based on extrapolated data from adult and animal studies. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has developed a Collaborative Pediatric Critical Care Research Network (CPCCRN) to transform Pediatric Critical Care from a pathophysiology based art to an evidence based scientific practice through innovative, cutting-edge, multi-disciplinary clinical investigations. The Children's Hospital of Philadelphia (CHOP) has been an outstanding CPCCRN Clinical Site from 2009-2014, led by Drs. Berg and Zipper. This proposal for CHOP to continue to be a CPCCRN site has three components: #1: To demonstrate CHOP's ability to be an outstanding CPCCRN Clinical Site. CHOP is a top ranked children's hospital with one of the largest pediatric research programs in the country: >$138 million/year in total federal awards and an annual budget >$329 million. CHOP has the nation's largest pediatric health care system, and is one of the nation's largest children's hospitals with >500 beds. CHOP's Critical Care Medicine Program is one of the largest in the nation with 55 PICU beds, 32 CICU beds, and 4200 admissions/year, providing a large and diverse patient base for clinical research. CHOP Critical Care Medicine has 9 investigators with =20% salary support from federal research funding, >180 peer-reviewed research publications in the last 3 years, and nationally recognized pediatric critical care clinicl research programs. #2: To demonstrate that CHOP has been an outstanding CPCCRN Clinical Site (2009-2014). From 2009-2014, CHOP has been the leading enrollment site for CPCCRN studies. Dr. Berg has led four CPCCRN CPR studies; Dr. Zipper has led two CPCCRN pharmacology studies; and Ms. Dilbert (CHOP CPCCRN Research Coordinator) has led a CPCCRN research coordinator education and management program. Specific Aim 3: To present a transformative research "concept proposal" that highlights our capabilities and strengths for development and design of high-impact cooperative protocols in the network: a life-saving approach to improve survival among children who need cardiopulmonary resuscitation (CPR). The Children's Hospital of Philadelphia is an ideal Clinical Site for CPCCRN, based on: 1) the outstanding resources, institutional commitment, programs, faculty, productivity, and future opportunities; 2) CHOP's performance as an outstanding CPCCRN Clinical Site from 2009-2014; and 3) the exciting "concept proposal" demonstrating our abilities to be CPCCRN leaders.