Pediatric Critical Care Research Network at Children's Hospital of Philadelphia

描述（由申请人提供）：儿科重症监护医学已发展为基于成人和动物研究外推数据的临床艺术。Eunice Kennedy Shriver国家儿童健康与人类发展研究所（NICHD）支持新生的儿科重症研究合作网络（CPCCRN），通过创新和尖端的多学科临床研究，将儿科重症监护从病理生理学为基础的艺术转变为循证科学实践。费城儿童医院（CHOP）是一家大型，多元化，多学科，研究密集型的儿科学术健康中心。CHOP在21^'世纪的五年研究愿景是“致力于儿童转化研究的卓越机构”。“这一愿景是对NICHD CPCCRN承诺的补充，以实现创新研究，并为重症儿童的护理提供更有力的科学证据基础。此外，CHOP的重症监护项目是临床重症监护研究的国际领导者。因此，CHOP重症监护项目是CPCRN的理想临床研究中心。CHOP重症监护组还有一个长期目标，即改善儿童心脏骤停后的结局。儿童心脏骤停是一个主要的公共卫生问题：美国每年有数千名儿童在医院内心脏骤停，另有数千名儿童在医院外心脏骤停。有效的心肺复苏术（CPR）可以挽救许多生命，但儿童CPR通常不符合救生CPR指南。我们的假设是，咨询性目标导向的实时自动儿科CPR反馈将：1）提高对CPR指南的依从性，2）从而使停搏后12个月时具有良好神经行为结局的出院存活率提高10%。 公共卫生相关性：通过这个研究网络为儿科重症监护提供强有力的科学依据，最终将挽救生命，改善我们最宝贵的商品--我们的孩子--的神经行为结果。CHOP CPR提案的目的是通过证明咨询目标导向的实时儿科CPR反馈改善了院内儿科心脏骤停的结果，从而改变儿科复苏领域。

DESCRIPTION (provided by applicant): Pediatric Critical Care Medicine has developed as a clinical art based on extrapolated data from adult and animal studies. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has supported a nascent Collaborative Pediatric Critical Research Network (CPCCRN) to transform Pediatric Critical Care from a pathophysiologically based art to an evidence-based scientific practice through innovative and cutting-edge, multi-disciplinary clinical investigations. Children's Hospital of Philadelphia (CHOP) is a large, diverse, multi-disciplinary, research intensive premiere pediatric academic health center. The 5-year research vision of CHOP in the 21^' century is to be "the preeminent institution dedicated to translational research for children." This vision is complementary to the commitment of the NICHD CPCCRN to achieve innovative research and provide a stronger scientific evidence basis for the care of the critically ill child. Moreover, the Critical Care programs at CHOP are international leaders in clinical critical care research. Therefore, the CHOP Critical Care Program is the ideal Clinical Site for the CPCRN. The CHOP Critical Care Group also has a long-term goal to improve outcomes following cardiac arrests in children. Cardiac arrests in children are a major public health problem: thousands of children in the U.S. have sudden cardiac arrests in hospitals each year and thousands more have out-of-hospital arrests. Many lives can be saved with effective cardiopulmonary resuscitation (CPR), yet CPR for children typically does not comply with life-saving CPR guidelines. Our hypothesis is that advisory goal-directed, real-time automated pediatric CPR feedback will: 1) improve compliance with CPR guidelines and, 2) thereby increase the rate of survival to hospital discharge with good neurobehavioral outcome at 12 months post-arrest by 10%. PUBLIC HEALTH RELEVANCE: Providing a strong scientific basis for pediatric critical care with this research network will ultimately save lives and improve neurobehavioral outcomes of our most precious commodity, our children. The intent of the CHOP CPR proposal is to transform the field of pediatric resuscitation by demonstrating that advisory goal- directed real-time pediatric CPR feedback improves outcomes from in-hospital pediatric cardiac arrests.