Pediatric Critical Care Research Network at Children's Hospital of Philadelphia

描述(由申请人提供)：儿科重症监护医学已经发展成为一门基于成人和动物研究的外推数据的临床艺术。尤尼斯·肯尼迪·施莱弗国家儿童健康与人类发展研究所(NICHD)支持了一个新成立的合作儿科危重研究网络(CPCCRN)，通过创新和尖端的多学科临床研究，将儿科危重护理从基于病理生理学的艺术转变为基于循证的科学实践。费城儿童医院(CHOP)是一家大型、多元化、多学科、研究密集的首屈一指的儿科学术健康中心。CHOP在21世纪的5年研究愿景是“致力于儿童翻译研究的卓越机构”。这一愿景是对NICHD CPCCRN实现创新研究并为照顾危重儿童提供更有力的科学证据基础的承诺的补充。此外，CHOP的重症监护项目在临床重症监护研究方面处于国际领先地位。因此，CHOP重症监护计划是CPCRN的理想临床地点。CHOP重症监护小组也有一个长期目标，以改善儿童心脏骤停后的预后。儿童心脏骤停是一个主要的公共卫生问题：在美国，每年有数千名儿童在医院发生心脏骤停，还有数千名儿童在医院外发生心脏骤停。有效的心肺复苏术(CPR)可以挽救许多生命，但儿童CPR通常不符合拯救生命的CPR指南。我们的假设是，咨询目标导向的、实时的儿科CPR自动反馈将：1)改善CPR指南的遵从性，2)从而将12个月后神经行为结果良好的出院存活率提高10%。 公共卫生相关性：通过这一研究网络为儿科危重护理提供强有力的科学基础，最终将拯救生命，并改善我们最宝贵的商品--我们的儿童--的神经行为结果。CHOP CPR提案的目的是通过证明咨询目标导向的实时儿科CPR反馈改善医院内儿科心脏骤停的预后，从而改变儿科复苏领域。

DESCRIPTION (provided by applicant): Pediatric Critical Care Medicine has developed as a clinical art based on extrapolated data from adult and animal studies. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has supported a nascent Collaborative Pediatric Critical Research Network (CPCCRN) to transform Pediatric Critical Care from a pathophysiologically based art to an evidence-based scientific practice through innovative and cutting-edge, multi-disciplinary clinical investigations. Children's Hospital of Philadelphia (CHOP) is a large, diverse, multi-disciplinary, research intensive premiere pediatric academic health center. The 5-year research vision of CHOP in the 21^' century is to be "the preeminent institution dedicated to translational research for children." This vision is complementary to the commitment of the NICHD CPCCRN to achieve innovative research and provide a stronger scientific evidence basis for the care of the critically ill child. Moreover, the Critical Care programs at CHOP are international leaders in clinical critical care research. Therefore, the CHOP Critical Care Program is the ideal Clinical Site for the CPCRN. The CHOP Critical Care Group also has a long-term goal to improve outcomes following cardiac arrests in children. Cardiac arrests in children are a major public health problem: thousands of children in the U.S. have sudden cardiac arrests in hospitals each year and thousands more have out-of-hospital arrests. Many lives can be saved with effective cardiopulmonary resuscitation (CPR), yet CPR for children typically does not comply with life-saving CPR guidelines. Our hypothesis is that advisory goal-directed, real-time automated pediatric CPR feedback will: 1) improve compliance with CPR guidelines and, 2) thereby increase the rate of survival to hospital discharge with good neurobehavioral outcome at 12 months post-arrest by 10%. PUBLIC HEALTH RELEVANCE: Providing a strong scientific basis for pediatric critical care with this research network will ultimately save lives and improve neurobehavioral outcomes of our most precious commodity, our children. The intent of the CHOP CPR proposal is to transform the field of pediatric resuscitation by demonstrating that advisory goal- directed real-time pediatric CPR feedback improves outcomes from in-hospital pediatric cardiac arrests.