Ohio State University Neuroscience Center Core

俄亥俄州立大学(OSU)神经科学中心核心，现已进入NINDS支持的第12个年头，提供 支持神经病学病因和治疗研究的专门知识和服务 精神错乱。该中心总共为40多名神经学家(20名由NINDS资助)提供服务，这些科学家来自多个 部门、中心和研究所，并已成为神经科学研究和合作的催化剂 穿过校园。优势领域包括神经退行性疾病的基础研究和翻译研究 神经肌肉疾病、脑肿瘤和神经创伤。该中心利用大量的机构 俄亥俄州立大学在研究基础设施和神经科学方面的投资和联邦支持。这包括最近的 成立了大脑和脊柱医院和神经科学研究所，这是一项数百万美元的努力 协调校园内约175名基础和临床神经学家的活动。该中心由一个 行政核心和四个科学核心，所有这些核心都已建立、运作和成功。这个 科学核心提供了以其他方式无法为个人提供的服务、设备和专门知识， 增强他们执行其资助项目目标的能力，并促进他们采用新的 方法和技术。科学核心的这种专业知识和设备的集中增加了 通过最大限度地减少工作和设备的重复，提高俄亥俄州立大学NINDS资助的研究的效率和质量， 并确保统一适用最佳做法。岩心由调查人员指导，具有深度和 在核心服务方面经过验证的专业知识。核心A(行政)制定政策，监督核心运营 和预算，并促进核心服务与校园神经科学家的沟通。核心安排 神经科学用户小组会议，以促进核心服务，确定新需求，并促进 跨核心协作。核心B(受伤)提供设备、培训和技术专长，包括 标准化和个性化的损伤方案，以支持脊髓和脑损伤的研究 啮齿动物的模型。核心C(行为)提供对设备的访问和熟练的技术专长 有必要对啮齿动物模型进行全面的行为表型分析，以及专家培训和 关于行为实验执行的咨询。CORE D(电生理学)提供专门的 监测和记录神经元电活动所需的设备、培训和技术专长 还有神经胶质细胞。核心E(成像)提供使用共焦显微镜的途径，包括专家培训、咨询 并协助对活的和固定的细胞、组织和胚胎进行荧光成像。总的来说，这些 CORES将支持NINDS资助的23个项目(包括12个符合条件的R01项目)，总额为750万美元 在年度资助中，加上其他14个由NIH资助的神经科学项目，年度资助总额为390万美元， 改善这些项目的研究环境，促进合作和互动研究 促进多学科方法和联合研究努力的环境。

The Ohio State University (OSU) Neuroscience Center Core, now in its 12th year of NINDS support, provides specialized expertise and services that support research into the causes and treatments of neurological disorders. The Center serves a total of more than 40 neuroscientists (20 NINDS-funded) from multiple departments, centers, and institutes, and has become a catalyst for neuroscience research and collaboration across campus. Areas of strength include basic and translational research on neurodegenerative and neuromuscular diseases, brain tumors and neurotrauma. The Center leverages substantial institutional investment and federal support in research infrastructure and neuroscience at OSU. This includes the recently formed Brain and Spine Hospital and the Neuroscience Research Institute, a multi-million dollar effort that aligns the activities of about 175 basic and clinical neuroscientists across campus. The Center comprises one Administrative Core and four Scientific Cores, all of which are established, functional and successful. The Scientific Cores provide access to services, equipment and expertise not otherwise available to individual PIs, enhancing their ability to execute the aims of their funded projects and facilitating their adoption of new approaches and technologies. This centralization of expertise and equipment in the Scientific Cores increases the efficiency and quality of NINDS-funded research at OSU by minimizing duplication of effort and equipment, and ensuring the uniform application of best practices. The Cores are directed by investigators with deep and proven expertise in the Core services. Core A (Administrative) sets policies, oversees the Core operations and budget, and facilitates communication of Core services to neuroscientists on campus. The Core arranges meetings of the Neuroscience User Group in order to promote core services, identify new needs, and promote cross-core collaborations. Core B (Injury) provides equipment, training and technical expertise, including standardized and well-characterized injury protocols, to support research on spinal cord and brain injury models in rodents. Core C (Behavior) provides access to the equipment and skilled technical expertise necessary to perform comprehensive behavioral phenotyping of rodent models, as well as expert training and consultation on the execution of behavioral experiments. Core D (Electrophysiology) provides specialized equipment, training and technical expertise necessary to monitor and record the electrical activity of neurons and glia. Core E (Imaging) provides access to confocal microscopes including expert training, consultation and assistance with fluorescence imaging of living and fixed cells, tissues and embryos. Collectively these Cores will support 23 NINDS-funded projects (including 12 qualifying R01 projects) totaling $7.5 million dollars in annual funding, plus 14 other NIH-funded neuroscience projects totaling $3.9 million in annual funding, enhancing the research environment for these projects and fostering a cooperative and interactive research environment in which multi-disciplinary approaches and joint research efforts are stimulated.