Enhancing Whole Genome Sequencing Surveillance Capacity in Pennsylvania through Participation in GenomeTrakr

1.项目总结/摘要 食品和药物管理局的GenomeTrakr计划是为了填充数据库 以及食源性病原体的基因组序列和相关元数据。…的状态 宾夕法尼亚州于2016年加入GenomeTrakr网络，作为宾夕法尼亚州的合资企业 州和宾夕法尼亚州卫生部(Padoh)。此次合作是 被设想为利用世界级基因组学专业知识和 生物信息学，以及宾夕法尼亚州立大学发现的独特的文化收藏， 帕度的流行病学和监测实力。自2017年1月以来，PA GenomeTrakr团队每月对大约48个分离物进行测序，而Padoh已经 成为管理项目的不可或缺的合作伙伴，同时也积极参与 发展基因组学和生物信息学方面的技能。这份建议书描述了我们对 未来两年：1)实现FDA用AT填充GenomeTrakr数据库的目标 每年至少400个基因组序列；2)整合基于序列的流行病学 对帕度正在进行的计划的方法，以及3)寻求长期机制 这项计划在宾夕法尼亚州的可持续性。

1. Project summary/abstract The Food and Drug Administration’s GenomeTrakr program exists to populate databases with genome sequences and associated metadata of foodborne pathogens. The state of Pennsylvania joined the GenomeTrakr network in 2016 as a joint venture between Penn State and the Pennsylvania Department of Health (PADOH). This collaboration was envisioned as a model for leveraging the world-class expertise in genomics and bioinformatics, and the unique culture collections found at Penn State, with the epidemiology and surveillance strengths of the PADOH. Since January 2017, the PA GenomeTrakr team is sequencing approximately 48 isolates per month, and the PADOH has become an integral partner in managing projects while also actively participating to develop skills in genomics and bioinformatics. This proposal describes our approach for the next two years to: 1) meet FDA goals of populating the GenomeTrakr databases with at least 400 genome sequences per year; 2) integrate sequence-based epidemiologic approaches into ongoing programs at the PADOH, and 3) Pursue mechanisms of long-term sustainability for this program in the state of Pennsylvania.