The Sylvester Cancer Center Support Grant

项目概要：总体 迈阿密大学的西尔维斯特综合癌症中心（西尔维斯特）寻求国家癌症 研究所（NCI）的指定，以支持其使命，以减少人类的负担，从癌症通过研究， 教育、预防和提供优质的病人护理。西尔维斯特，唯一的学术癌症中心 位于南佛罗里达，服务于美国最多样化的集水区之一。这四个县的地区 （布劳沃德，迈阿密-戴德，门罗和棕榈海滩县），俗称南佛罗里达，是家庭， 超过600万居民，其特点是大量的民族，文化，种族和社会经济 多样性，反映在西尔维斯特治疗的个人和那些受其外联工作影响的人身上。 由Stephen D.自2012年以来，西尔维斯特领导层组建了一个高度协作的团队， 调查人员现在包括来自三所大学的114名癌症科学家。西尔维斯特的 研究分为三个研究项目--癌症控制、癌症表观遗传学和肿瘤 生物学这些计划是统一的交叉科学主题和西尔维斯特的更广泛的使命， 解决癌症负担和其服务区域内普遍存在的差异。西尔维斯特投入巨资 这些研究项目和四个最先进的共享资源，支持西尔维斯特的癌症 研究人员：生物统计学和生物信息学，肿瘤基因组学，流式细胞术，行为和 以社区为基础的研究共享资源 西尔维斯特还在其临床研究基础设施上投入巨资，这导致了大幅增加 在介入治疗应计费用中（从2011年的75人增加到2017年的509人），4，568名患者中有50%以上 2017年，少数民族/少数民族的代表。大学作出了重大承诺， 自2012年以来，提高了西尔维斯特的研究能力，支持招募41名癌症研究人员 并将癌症中心的空间扩大一倍。西尔维斯特还扩大了博士前和博士后的培训工作 横跨临床、基础、转化和人口科学，最近获得了五项奖励。 获得NIH或NCI资助的T32培训赠款，具有重要培训组成部分的U 54补助金，以及保罗 卡拉布雷西K12赠款。最后，西尔维斯特已投资约570万美元的校内资助计划，从 2014年至2018年，已获得2520万美元的同行评审资金。今天，西尔维斯特在校外有3800万美元的资金 研究经费（包括培训赠款），其中包括来自NCI的1100万美元;这占12%， 64%，分别比去年同期增长。 这些令人印象深刻的成就创造了一种文化和环境，使西尔维斯特科学家能够 对癌症生物学的理解和新方法的开发做出了宝贵的贡献 癌症的预防、诊断和治疗。

PROJECT SUMMARY: OVERALL The Sylvester Comprehensive Cancer Center (Sylvester) at the University of Miami seeks National Cancer Institute (NCI) designation to support its mission to reduce the human burden from cancer through research, education, prevention, and the delivery of quality patient care. Sylvester, the only academic Cancer Center located in South Florida, serves one of the most diverse catchment areas in the US. This four-county region (Broward, Miami-Dade, Monroe, and Palm Beach Counties), commonly known as South Florida, is home to more than six million residents and is characterized by substantial ethnic, cultural, racial, and socioeconomic diversity, reflected in the individuals treated by Sylvester and those affected by its outreach efforts. Led by Stephen D. Nimer, MD since 2012, Sylvester leadership has assembled a highly collaborative group of investigators that now includes 114 cancer scientists from three University Schools and Colleges. Sylvester’s research is organized into three Research Programs—Cancer Control, Cancer Epigenetics, and Tumor Biology. These programs are unified by crosscutting scientific themes and by Sylvester’s broader mission to address the cancer burden and disparities prevalent in its catchment area. Sylvester has invested heavily in these Research Programs and in four state-of-the-art shared resources that support Sylvester’s cancer researchers: the Biostatistics and Bioinformatics, Onco-Genomics, Flow Cytometry, and Behavioral and Community-Based Research Shared Resources. Sylvester has also invested heavily in its clinical research infrastructure, which has led to a dramatic increase in interventional treatment accruals (from 75 in 2011 to 509 in 2017), with more than 50% of the 4,568 patient accruals in 2017 representing racial/ethnic minorities. The University has made a substantial commitment to advancing Sylvester’s research capabilities since 2012, supporting the recruitment of 41 cancer researchers and doubling Cancer Center space. Sylvester has also expanded its pre- and post-doctoral training efforts across the clinical, basic, translational, and population sciences, which have been rewarded with five recently awarded NIH or NCI-funded T32 training grants, a U54 grant with a significant training component, and a Paul Calabresi K12 grant. Finally, Sylvester has invested roughly $5.7M in its Intramural Funding Program from 2014 to 2018, which has yielded $25.2M in peer-reviewed funding. Today, Sylvester has $38M in extramural research funding (including training grants), which includes $11M from the NCI; this represents a 12% and 64% increase, respectively, over the past year. These impressive achievements have created a culture and environment that enable Sylvester scientists to make valuable contributions to the understanding of cancer biology and the development of novel approaches to cancer prevention, diagnosis, and treatment.