An evaluation of a social network intervention for primary and secondary prevention of opioid overdoses.

项目摘要 这项研究是一项针对阿片类药物滥用者及其药物网络的随机临床试验 评估实验性同伴指导条件对(A)过量用药预防和护理的效果 对毒品网络成员的教育，(B)纳洛酮的供应，和(C)戒毒准备情况 然后进入。建议的研究是根据我们先前的研究、先导研究和 其他研究人员的研究表明，社交网络可以被资本化 制定强有力和可持续的干预措施，以改变阿片类药物使用者的行为。 300名指数参与者将参加这项研究。指数参与者将被要求在 至少1名网络成员，同时也是当前的阿片类药物使用者。一半的指数参与者将是 随机分配给比较条件，一半分配给实验条件(PEER 导师干预)，由3个单独的会议组成，重点是教育他们的 促进药物治疗、预防和护理过量用药并提供 纳洛酮给网络成员。指数和网络参与者将通过面对面的 3个月、6个月、9个月和12个月的面谈和药物毒理学。预计通过积极的 学习、认知不和谐和社会认同过程，索引参与者在 实验条件将更容易改变他们的用药过量行为，并增加 治疗准备情况与处于同等注意力比较条件下的患者进行比较。社交 扩散行为的变化也将被评估在网络成员的指标中。 还将鼓励指数参与者招募家人和朋友接受纳洛酮和 我们社区诊所的药物过量预防和护理培训。在为期6个月的评估中， 根据我们先前研究中的戒毒治疗入院率，我们预计至少有250人 指数参与者不会接受药物治疗，但会被指定接受治疗。两者中的索引 在为期6个月的评估中报告使用药物的情况将得到单独的治疗 专注于药物治疗的进入和药物治疗作为成为同龄人的下一个合乎逻辑的步骤 门托。在为期9个月的评估中，将为指数提供第二次药物治疗 符合药物依赖和药物治疗标准的人。

Project Summary The study is designed as a randomized clinical trial of opiate abusers and their drug networks to assess efficacy of the experimental Peer Mentor condition on (a) overdose prevention and care education to drug network members, (b) naloxone availability, and (c) drug treatment readiness and entry. The proposed study is based on our previous research, pilot studies, and the research of other investigators who have demonstrated that social networks can be capitalized on to develop robust and sustainable interventions for behavior change among opiate users. 300 index participants will be enrolled in the study. Index participants will be asked to recruit at least 1 network member who is also a current opiate user. Half of the index participants will be randomly assigned to the comparison condition and half to the experimental condition (peer mentor intervention), which consists of 3 individual sessions focused on education of their network members for promoting drug treatment, overdose prevention and care, and providing naloxone to network members. Index and network participants will be assessed with face-to- face interviews and drug toxicology at 3, 6, 9, & 12 months. It is anticipated that through active learning, cognitive dissonance, and social identity processes, index participants in the experimental condition will be more likely to change their drug overdose behaviors and increase treatment readiness as compared to those in the equal attention comparison condition. Social diffusion of behavior change will also be assessed in the network members of the indexes. Index participants will also be encouraged to recruit family and friends to receive naloxone and overdose prevention and care training at our community clinic. At the 6-month assessment, based on drug treatment enrollment rates in our prior studies, we expect at least 250 of the index participants will not be in drug treatment but indicated for treatment. Indexes in both conditions who report using drugs at the 6-month assessment will receive an individual session focused on drug treatment entry and drug treatment as the next logical step in being a Peer Mentor. At the 9-month assessment, a second drug treatment session will be offered to indexes who meet criteria for drug dependence and drug treatment.