Health disparities, stress pathways, and stress-related comorbidities among MSM living with HIV

HIV 感染者中 MSM 的健康差异、压力途径和压力相关合并症

基本信息

  • 批准号:
    9651006
  • 负责人:
  • 金额:
    $ 73.51万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-09-01 至 2023-03-31
  • 项目状态:
    已结题

项目摘要

Project Summary Stress is associated with HIV risk behaviors, immune dysregulation, and among people living with HIV (PLWH) it has been associated with viral load and disease progression. The goal of this study is to better understand the mechanisms of stress and stress-related comorbidities and how they exacerbate HIV-related health disparities among HIV-infected Black men who have sex with men (BMSM). Studies in many parts of the US suggest that BMSM often live or spend much of their time in impoverished neighborhoods where physical and social disorders (e.g., physical decay, violence, discrimination) are clustered. These socio-structural factors can be conceptualized as chronic and acute stressors and may promote other stressors that lead to HIV-related outcomes. While much of the literature on minority stress has focused on major discriminatory events, this proposed study will examine microaggressions. We will comprehensively assess chronic, acute, and daily psychosocial stressors that are particularly relevant to MSM, especially BMSM. Moreover, we will use measures of hypothalamic–pituitary– adrenal (HPA) axis responses, sympathetic nervous system (SNS), and inflammatory biomarkers to identify specific stress pathways among HIV-infected BMSM and White MSM (WMSM) that can be targeted in future interventions. We aim to provide an extension of minority stress theory by utilizing intensive longitudinal protocols to assess daily discriminatory events and other stressors, and to explore the association with HIV-related behaviors and physiological outcomes. Built upon the evidence of feasibility and acceptability from our previous research, this aim will be accomplished by using ecological momentary assessment (EMA) of stressors and stress, Medication Event Monitoring System (MEMS), and home-based testing for cortisol. We propose a longitudinal study of 450 HIV-infected BMSM and WMSM who have common stress-related comorbidities (e.g., cardiovascular disease, depression, substance abuse) assessed at baseline, 6, 12, 18, and 24 months. Participants will provide 9 days of smartphone- based EMA and MEMS for ART medication adherence every 6 months for 24 months. Every 6 months, we will collect stress and immune function biomarkers.
项目总结

项目成果

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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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CARL A LATKIN其他文献

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{{ truncateString('CARL A LATKIN', 18)}}的其他基金

A social diffusion fatal overdose prevention intervention: Assessing the effectiveness of people who use opioids as peer educators in training using & non-using networks on overdose & stigma reduction
社会扩散致命过量预防干预措施:评估使用阿片类药物的人作为同伴教育者在培训中的有效性
  • 批准号:
    10716356
  • 财政年份:
    2023
  • 资助金额:
    $ 73.51万
  • 项目类别:
A social network approach for improving medication assisted treatment and HIV prevention and medical care among people who inject drugs in Ukraine
用于改善乌克兰注射吸毒者的药物辅助治疗、艾滋病毒预防和医疗保健的社交网络方法
  • 批准号:
    10676829
  • 财政年份:
    2021
  • 资助金额:
    $ 73.51万
  • 项目类别:
A social network approach for improving medication assisted treatment and HIV prevention and medical care among people who inject drugs in Ukraine
用于改善乌克兰注射吸毒者的药物辅助治疗、艾滋病毒预防和医疗保健的社交网络方法
  • 批准号:
    10491775
  • 财政年份:
    2021
  • 资助金额:
    $ 73.51万
  • 项目类别:
A social network approach for improving medication assisted treatment and HIV prevention and medical care among people who inject drugs in Ukraine
用于改善乌克兰注射吸毒者的药物辅助治疗、艾滋病毒预防和医疗保健的社交网络方法
  • 批准号:
    10321719
  • 财政年份:
    2021
  • 资助金额:
    $ 73.51万
  • 项目类别:
A geospatial analysis of hotspots and targeted injection settings pilot intervention for HIV prevention among people who inject drugs in Baltimore, Maryland
对马里兰州巴尔的摩注射吸毒者的艾滋病毒预防热点地区和有针对性的注射设置试点干预进行地理空间分析
  • 批准号:
    10402888
  • 财政年份:
    2020
  • 资助金额:
    $ 73.51万
  • 项目类别:
A geospatial analysis of hotspots and targeted injection settings pilot intervention for HIV prevention among people who inject drugs in Baltimore, Maryland
对马里兰州巴尔的摩注射吸毒者的艾滋病毒预防热点地区和有针对性的注射设置试点干预进行地理空间分析
  • 批准号:
    10079583
  • 财政年份:
    2020
  • 资助金额:
    $ 73.51万
  • 项目类别:
A geospatial analysis of hotspots and targeted injection settings pilot intervention for HIV prevention among people who inject drugs in Baltimore, Maryland
对马里兰州巴尔的摩注射吸毒者的艾滋病毒预防热点地区和有针对性的注射设置试点干预进行地理空间分析
  • 批准号:
    10203907
  • 财政年份:
    2020
  • 资助金额:
    $ 73.51万
  • 项目类别:
Health disparities, stress pathways, and stress-related comorbidities among MSM living with HIV
HIV 感染者中 MSM 的健康差异、压力途径和压力相关合并症
  • 批准号:
    10364643
  • 财政年份:
    2018
  • 资助金额:
    $ 73.51万
  • 项目类别:
Health disparities, stress pathways, and stress-related comorbidities among MSM living with HIV
HIV 感染者中 MSM 的健康差异、压力途径和压力相关合并症
  • 批准号:
    9765389
  • 财政年份:
    2018
  • 资助金额:
    $ 73.51万
  • 项目类别:
Health disparities, stress pathways, and stress-related comorbidities among MSM living with HIV
HIV 感染者中 MSM 的健康差异、压力途径和压力相关合并症
  • 批准号:
    9892889
  • 财政年份:
    2018
  • 资助金额:
    $ 73.51万
  • 项目类别:

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