Evaluating the impact of a brief, phone-based emotion regulation intervention on emotion perception within a transdiagnostic, clinical sample of adults.

项目摘要/摘要 尽管人际功能障碍在许多精神疾病中很常见，但缺乏 跨诊断、行为干预，解决这种功能障碍背后的社会认知问题。 情绪感知缺陷，即感知他人情绪的能力，是关键的社交过程之一 在NIMH研究领域标准(RDoC)框架中强调，这些标准与许多严重的 精神障碍。需要更多的研究来确定并干预导致这些缺陷的过程 在以情绪困难为特征的障碍中(例如，抑郁症、边缘人格障碍)。一 潜在的目标是情绪失调，难以管理负面情绪体验，因为 初步证据表明，它可能会损害情绪感知。因此，政府的首要目标是 建议的研究是测试情绪调节干预是否可以改善患者的情绪感知 情绪失调症成人的临床样本。这个项目将是实验室的后续项目 之前曾进行过一项初步研究，证明了一种简短、可概括的情绪调节的有效性 减少情绪唤醒和痛苦的干预立即在实验室内进行，并在实验室外超过一周 实验室(R01MH095806)。这项拟议的研究将系统地建立在该研究计划的基础上，并评估 这种干预对从面部感知他人情绪时的负面偏向的影响 表情。这项拟议研究的具体目的是评估这种干预措施对负面影响。 情绪感知偏差(1)在实验室培训课程内和(2)在实验室外超过一周 使用手机提醒功能。该项目将为处理社会问题的新方法提供基础 使用简短的、可获得的、基于技术的干预措施的流程，符合NIMH的“开发”使命 基于行为科学发现的新治疗方法。申请者将获得这方面的研究经验。 临床试验，由罗森塔尔博士(赞助商)领导。申请人的长期职业目标是成为一名独立的 为广泛人群开发这种干预措施的研究人员，包括那些典型的 在精神病学方面服务不足。拟议的项目整合了培训和研究计划，以开发申请者的 专业知识，奖学金基金允许在(1)进行转化性治疗研究方面进行指导培训； (2)新的干预技术(如移动电话)；(3)高级统计分析；(4)赠款和 陈述技能；以及(5)涉及不同临床人群的伦理问题和实践。这些目标将 通过课程作业、赞助商的指导、工作坊和研讨会以及开展 提出研究课题。这项奖学金将为申请者提供必要的支持，以发展 情绪、社会认知和临床科学方面的专业技能，以及使用 尖端数字技术。

PROJECT SUMMARY / ABSTRACT Although interpersonal dysfunction is common within many psychiatric illnesses, there is a lack of transdiagnostic, behavioral interventions addressing problematic social cognition underlying such dysfunction. Deficits in emotion perception, the ability to perceive other people’s emotions, are one of the key social processes emphasized in the NIMH Research Domain Criteria (RDoC) framework that are associated with many serious psychiatric disorders. More research is needed to identify and intervene on processes that cause these deficits in disorders characterized by emotional difficulties (e.g. depression, borderline personality disorder). One potential target is emotion dysregulation, difficulties managing negative emotional experiences, because preliminary evidence suggests that it may impair emotion perception. As such, the overarching goal of the proposed research is to test whether an emotion regulation intervention can improve emotion perception in a transdiagnostic, clinical sample of adults with emotion dysregulation. This project will be a follow-up to the lab’s previously conducted pilot study that demonstrated efficacy of a brief, generalizable emotion regulation intervention in reducing emotional arousal and distress immediately within the lab and over one week outside the lab (R01MH095806). This proposed study will build systematically on this research program and evaluate the effects of this intervention on negative biases when perceiving other people’s emotions from facial expressions. The specific aims of this proposed study are to evaluate the impact of this intervention on negative biases in emotion perception (1) within a laboratory-based training session and (2) outside the lab over one week using mobile phone reminders. The project will provide a foundation for a new way to treat problems in social processes using brief, accessible, technology-based interventions, in line with NIMH’s mission of “developing new treatments based on discoveries in behavioral science.” The applicant will gain research experience on this clinical trial, led by Dr. Rosenthal (sponsor). The applicant’s long-term career goal is to become an independent researcher who develops such interventions for a wide range of populations, including those typically underserved in psychiatry. The proposed project integrates training and research plans to develop the applicant’s expertise, with fellowship funds allowing for mentored training in (1) conducting translational treatment research; (2) novel intervention technologies (e.g. mobile phones); (3) advanced statistical analyses; (4) grant-writing and presentation skills; and (5) ethical issues and practices involving diverse clinical populations. These goals will be achieved through coursework, mentorship by the sponsors, workshops and seminars, and conducting the proposed research project. This fellowship will provide the necessary support for the applicant to develop a specialized skill set in emotion, social cognition, and clinical science, as well as intervention development using cutting-edge digital technologies.