Admin-Core-001

行政核心的总体目标是提供与所有人相关的领导和一般行政 项目“肺癌病因和风险综合分析”的方方面面。这一核心将是 负责将科学学科和研究地点整合为统一的跨学科方法。 这种方法的重点是与正在系统评估的大规模协作工作合作 吸烟行为与肺癌病因学、基因变异及其对肺癌影响的大规模研究 风险，以及为肺癌发展风险提供信息的生物标志物的开发和评估。要实现 我们的目标，我们的科学议程包括一系列三个相互关联的项目。我们的团队 调查人员是多学科的，建立在我们互补优势的基础上。这一核心将负责 管理所有项目和核心资源，并将确保符合所有政府和具体的NIH 条例和要求，包括与项目办公室和其他机构及时沟通和协商 NCI的工作人员。核心将召开所有必要的会议，包括内部指导的每月会议 委员会和外部科学咨询委员会年会。此外，每月的网络研讨会将 组织将具有本提案所依据的各个学科的专业知识的演讲者聚集在一起 沉着镇定。 本核心的具体目标是：具体目标1.维护和进一步开发一个数据库，以 流行病学和遗传数据。这一目标支持统一流行病学数据的大型数据库，并 还为匹配遗传信息的分发提供支持。 目标2.为计划项目活动提供综合支持。这个核心的主要功能是 确保计划项目关系和沟通的有效运作。目标3.确保 计划项目是否符合所有法规要求。行政核心支持 支持研究的方案的开发。它还协调与DBGaP和其他 需要或请求数据传输的实体。它还将管理与NCI的所有通信 方案、技术和行政人员。目标4.提供财政监督和管理。这个 行政核心监督财务管理，确保及时管理财务关系 在这些项目和核心中。

The overall goal of the Administrative Core is to provide leadership and general administration related to all aspects of the program project ‘Integrative Analysis of Lung Cancer Etiology and Risk’. This Core will be responsible for integrating the scientific disciplines and study sites into a unified interdisciplinary approach. This approach is focused on working with large-scale collaborative efforts that are systematically evaluating smoking behaviors and lung cancer etiology, large-scale studies of genetic variation and impact on lung cancer risk, and development and evaluation of biomarkers that inform risk for lung cancer development. To achieve our goals, our scientific agenda comprises a series of three inter-related program projects. Our team of investigators is multidisciplinary, building upon our complementary strengths. This Core will be responsible for managing all project and core resources and will ensure compliance with all governmental and specific NIH regulations and requirements, including timely communication and consultation with project offices and other NCI staff. The core will convene all necessary meetings, including monthly meetings of the internal steering committee and annual meeting of the external scientific advisory committee. In addition, monthly webinars will be organized to bring together speakers with expertise in the various disciplines upon which this proposal is composed. The specific aims of this Core are: Specific Aim 1. Maintain and further develop a database for epidemiological and genetic data. This aim supports a large database of harmonized epidemiological data and also provides support for distribution of matching genetic information. Aim 2. Perform Integrative Support for Program Project Activities. The primary function of this core is to ensure the efficient functioning of Program Project relationships and communication. Aim 3. Ensure compliance of the Program Project with all Regulatory Requirements. The administrative core supports the development of protocols that support studies. It also coordinates relationships with dbGAP and other entities for whom data transfers are required or requested. It will also manage all communications with NCI programmatic, technical and administrative staff. Aim 4. Provide fiscal oversight and management. The administrative core oversees financial management and ensures timely management of financial relationships among the Projects and Cores.