Training in Research Program on Alcohol Use by Persons with our at Risk for HIV

摘要我请求为K24 AA022586的5年续期提供资金，“培训和研究方案” 艾滋病毒携带者或高危人群饮酒“。在最初的K24资助期内，我的研究计划 在酒精对艾滋病毒风险的影响和酒精后果的观察性研究中取得了进展 通过新的U01和R01资金进行的干预研究。这些研究利用酒精生物标记物 (磷脂酰乙醇乙酯和乙基葡萄糖醛酸乙酯-EtG)和定期监测酒精含量的生物传感器 汗液(透皮酒精)作为客观结果衡量标准和干预工具(基于激励 干预)。在此期间，我的导师也在出版方面取得了成功(41个导师优先- 作者出版物)和赠款资助(K01、R36、R34、R01和U01提案的8个奖项)。我提议 续订这笔K24资金，以两种新的方式在此研究和指导成功的基础上再接再厉。(1)我建议 扩展我的酒精/艾滋病毒研究指导，包括酒精生物标记物和 生物传感器。这包括指导学者通过生物标记物或生物传感器研究酒精测量(例如 探索生物标记与生物传感器的组合，检查生物传感器和护理点生物标记的使用 真实世界等)。它还包括指导进行艾滋病毒共病研究的调查人员(例如： 结核病、病毒性肝炎、多物质使用)和脆弱人群(即青少年、感染艾滋病毒的婴儿-- 受感染的女性，那些经历亲密伴侣暴力的人)将饮酒的作用纳入他们的 研究，使用生物标志物或生物传感器。为了便于对我的指导进行这些扩展，我将使用K24 为学员主导的试点项目提供生物标志物和生物传感器续订资金。(2)我建议深思熟虑 加强对被认定为代表不足少数群体的人的指导的步骤，从而扩大 艾滋病毒研究人员的劳动力来自受药物使用影响不成比例的人群 (包括酒精)和艾滋病毒。拟议的K24研究部分将利用宝贵的数据来源来 给予学员生物标记物和生物传感器的研究经验。这些将是(1)将数据从多个 对5000多名参与者进行了酒精研究，并进行了心跳试验，以检验心跳试验阳性的相关性，最优 (2)利用饮酒者佩戴酒精生物传感器28天的数据，进一步 (3)检测低成本、临床点尿EtG检测阳性的相关性。 在目前一项对危险饮酒者的研究中进行了测试。作为一个研究领导者和一个 导师，我建议在快速发展的酒精生物标记物/生物传感器的前沿进行额外的培训 此外，他们还接受了培训，使其成为一名以URM身份认同的人的文化响应导师。总而言之，这是 K24支持的研究和导师培训将通过证明培训在以下方面促进酒精/艾滋病毒研究领域的发展 酒精生物标记物/生物传感器工具并将其应用于酒精/艾滋病毒问题，并将培训放在优先位置 来自URM群体的科学家们受到酒精和艾滋病毒的影响不成比例。

Abstract I am requesting funding for a 5-year renewal of K24 AA022586, “Training and Research Program on Alcohol use by Persons with or At-Risk for HIV”. Over this initial K24 funding period, my research program has flourished, progressing from observational studies of alcohol's impact on HIV risk and outcomes to alcohol intervention studies via new U01 and R01 funding. These studies leverage alcohol biomarkers (phosphatidylethanol – PEth and ethyl glucuronide – EtG) and biosensors that regularly monitor alcohol in sweat (transdermal alcohol) as objective outcome measures and as intervention tools (for incentive-based interventions). My mentees have also achieved success during this period in publishing (41 mentee first- authored publications) and grant funding (8 awards for K01, R36, R34, R01, and U01 proposals). I propose to renew this K24 funding to build upon this research and mentoring success in two new ways. (1) I propose to expand my alcohol/HIV research mentoring by including training in the use of alcohol biomarkers and biosensors. This includes mentoring scholars to study alcohol measurement via biomarkers or biosensors (e.g. exploring combinations of biomarkers with biosensors, examining biosensor and point-of-care biomarker use in the real world, etc.). It also includes mentoring investigators conducting research in HIV comorbidities (e.g. tuberculosis, viral hepatitis, polysubstance use) and in vulnerable populations (i.e. adolescents, infants of HIV- infected women, those experiencing intimate partner violence) to incorporate the role of alcohol use into their research, using biomarkers or biosensors. To facilitate these expansions to my mentoring, I will use K24 renewal funds for biomarkers and biosensors for mentee-led pilot projects. (2) I propose to take deliberate steps to increase mentoring of persons who identify as under-represented minorities (URM) thereby expanding the workforce of HIV researchers from populations that are disproportionately affected by substance use (including alcohol) and HIV. The proposed K24 research component will leverage valuable data sources to give mentees biomarker and biosensor research experience. These will be (1) pooling data from several alcohol studies with over 5000 participants with PEth testing, to examine correlates of PEth positivity, optimal cutoffs, and moderators; (2) leveraging data from drinkers wearing alcohol biosensors for 28 days, to further examine PEth cutoffs, and (3) examining correlates of test positivity of a of low-cost, point-of-care urine EtG test in a current study of hazardous drinkers. To be maximally effective as both a research leader and a mentor, I propose additional training to be at the forefront of the rapidly evolving alcohol biomarker/biosensor fields, and also training to be a culturally responsive mentor for persons who identify as URM. In summary, this K24-supported research and mentor training will grow the alcohol/HIV research field by proving training in alcohol biomarker/biosensor tools and applying them to alcohol/HIV issues, and by prioritizing training for scientists from URM groups that are disproportionately affected by alcohol and HIV.