Oklahoma IDeA Network of Biomedical Research Excellence

项目摘要 俄克拉荷马州IDEA生物医学研究卓越网络（OK-INBRE）的更新申请 建议进一步加强全州的研究基础设施和生物医学研究能力， 俄克拉荷马州：i）建立在我们建立的OK-INBRE研究网络的基础上，以科学为重点，加强 牵头机构和伙伴机构的生物医学研究专长和基础设施，ii）增加研究 通过为OK-INBRE的教师、博士后研究员和研究生提供支持，提高俄克拉荷马州的能力 网络伙伴机构，iii）为主要是本科生的学生提供研究机会 机构（PUI），社区学院（CC）和少数民族服务机构作为新的“管道” 学生进入健康研究事业，以及iv）提高科学和技术知识， 俄克拉荷马州的劳动力。OK-INBRE网络由两个研究密集型机构组成， 俄克拉荷马州大学健康科学中心（OUHSC）和俄克拉荷马州医学研究基金会 （OMRF）。这些机构与六个PUI和四个CC相结合，对 OK-INBRE网络的成功。全州范围内的OK-INBRE网络包括兰斯顿大学，唯一的 历史上，俄克拉荷马州的黑人大学和东北州立大学是PUI中人数最多的大学。 美国任何四年制大学的美国印第安人。另外，俄克拉荷马州唯一被认可的部落学院， 沿着与其他四个PUI和三个额外的CC包括教育大量的学生从 代表性不足的群体。科学主题是多学科的，涵盖癌症、 发育生物学和传染病。OK-INBRE将提供重要的研究资源， 八名研究项目调查员（RPI），四名来自OUHSC/OMRF，四名来自网络PUI。 每个科学主题的具体职业发展和指导委员会将帮助RPI实现 科学独立。此外，将为研究和设备提供较小的发展赠款。 每年提供给PUI教师。每年还将为35名本科生提供支持， 提供一个充满活力和充满活力的夏季本科研究计划。OK-INBRE将支持 生物信息学和蛋白质组学的核心设施，将作为全州的研究和教育资源 为全州的教师、学员和学生提供所需的计算工具， 加强俄克拉荷马州的多学科生物医学研究。独特的是，蛋白质组学核心不仅将发挥 在俄克拉荷马州培训下一代研究人员的核心作用，但它也将被用作资源， 所有符合IDEA资格的州的研究者。通过讲习班、研讨会、研究培训、指导和 获得最先进的核心设施，OK-INBRE计划将继续加强基础设施， 研究能力，同时提高俄克拉荷马州劳动力的整体科学和技术知识。

Project Summary This renewal application for the Oklahoma IDeA Network for Biomedical Research Excellence (OK-INBRE) proposes to further enhance the statewide research infrastructure and biomedical research capacity in Oklahoma by: i) building on our established OK-INBRE research network with a scientific focus to strengthen the lead and partner institutions' biomedical research expertise and infrastructure, ii) increasing the research capacity of Oklahoma by providing support to faculty, postdoctoral fellows and graduate students at OK-INBRE network partner institutions, iii) providing research opportunities for students from primarily undergraduate institutions (PUI), community colleges (CC), and minority serving institutions to serve as a "pipeline" for new students to enter into health research careers, and iv) enhancing the science and technology knowledge of Oklahoma's workforce. The OK-INBRE Network is comprised of two research intensive institutions, the University of Oklahoma Health Sciences Center (OUHSC) and the Oklahoma Medical Research Foundation (OMRF). These institutions are integrated and aligned with six PUIs and four CCs that are essential to the success of the OK-INBRE network. The statewide OK-INBRE network includes Langston University, the only Historically Black University in Oklahoma, and Northeastern State University, a PUI with the highest number of American Indians of any four year college in the nation. Additionally, Oklahoma's only accredited tribal college, along with four other PUIs and three additional CCs are included that educate large numbers of students from underrepresented groups. The scientific themes are multi-disciplinary and span the areas of Cancer, Developmental Biology, and Infectious Diseases. OK-INBRE will provide significant research resources to eight Research Project Investigators (RPIs), four from OUHSC/OMRF and four from the network PUIs. Specific career development and mentoring committees for each scientific theme will help the RPIs achieve scientific independence. In addition, smaller developmental grant awards for research and equipment will be provided to PUI faculty annually. Support for 35 undergraduate students also will be provided each year to provide a vibrant and dynamic summer undergraduate research program. OK-INBRE will support Bioinformatics and Proteomics Core facilities that will serve as statewide research and educational resources to provide faculty, trainees, and students throughout the state with access to the computational tools needed to enhance multidisciplinary biomedical research in Oklahoma. Uniquely, the Proteomics Core will not only play a central role in training the next generation of researchers in Oklahoma, but it will also be used as a resource for investigators in all IDeA-eligible states. Through workshops, seminars, research training, mentoring, and access to state-of-the-art core facilities, the OK-INBRE program will continue to enhance infrastructure and research capacity while increasing the overall science and technology knowledge of the Oklahoma workforce.