Pediatric Brain Imaging

许多精神疾病的风险基础，包括那些成人发病，越来越多地被理解为神经发育异常。 在这项纵向研究中（参与者大约每隔两年返回一次），我们将联合收割机脑成像信息与广泛的行为和神经心理学测试以及遗传数据相结合，以探索典型和非典型发育中基因、大脑和行为之间的关系。 了解大脑发育的典型路径对于评估疾病是否与偏离该路径有关至关重要。为此，我们获得了世界上最大的具有良好特征的纵向儿科脑部MRI扫描数据集（N = 1000）。 这些数据为世界各地的许多神经成像项目提供了资源，并导致了对青少年情感，认知和行为生物学的关键见解。 为了评估先天/后天问题，我们正在研究单卵双胞胎和双卵双胞胎的大脑发育。 对X和Y染色体数量变化（即XXY、XXX、XYY、XXXXY）和激素异常（即库欣病、先天性肾上腺增生、家族性早熟）的受试者的研究使我们能够辨别激素和染色体对大脑中男性/女性差异的相对贡献。 研究的临床人群包括ADHD和儿童期发作精神分裂症的最大影像学研究。 在这些领域中的每一个领域都对文献作出了重要贡献。

The foundations of risk for many psychiatric disorders, including those with adult onset, are increasingly understood as arising from anomalies of neurodevelopment. In this longitudinal study (with participants returning at approximately two-year intervals) we combine brain imaging information with extensive behavioral and neuropsychological testing as well as genetic data to explore the relationship between genes, brain, and behavior in typical and atypical development. Understanding the typical path of brain development is imperative to assess whether illness are associated with deviations from that path. To this end we have acquired the worlds largest data set of well-characterized longitudinal pediatric brain MRI scans (N = 1000). This data serves as a resource for many neuroimaging projects throughout the world and has led to key insights into the biology of adolescent emotion, cognition, and behavior. To assess nature/nurture questions we are studying brain development in mono and dizygotic twins. The study of subjects with variations in the number of X and Y chromosomes (i.e. XXY, XXX, XYY, XXXXY) and subjects with hormone anomalies (i.e. Cushings disease, Congenital Adrenal Hyperplasia, Familial Precocious Puberty) allow us to discern the relative contributions of hormones and chromosomes to male/female differences in the brain. Clinical populations investigated include the largest imaging studies of ADHD and Childhood-Onset Schizophrenia. Seminal contributions to the literature have been produced in each of these areas.