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Neuregulin in the development of hippocampal neurons

Neuregulin in the development of hippocampal neurons
神经调节蛋白在海马神经元发育中的作用
批准号：
7594606
负责人：
Zheng Li
金额：
$58.95万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7594606
关键词：
Chromosome PairingCognitiveDefectDevelopmentDiseaseEnvironmentGene MutationGenesGenomeGrowthHippocampus (Brain)KnowledgeLaboratoriesLawsMental DepressionMental disordersMorphogenesisNeuregulinsNeuronsProcessProtein IsoformsProtein OverexpressionRiskSchizophreniaSynapsesSynaptic Transmissionexperiencegene functionneural circuitprograms

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中文摘要
翻译
我们正在研究海马神经元中过度表达neuregulin的亚细胞定位和影响。我们观察到neuregulin在海马神经元中以簇的形式存在。我们正在研究这些神经调节蛋白簇是否与特定的亚细胞区室有关。我们也在分析过度表达neuregulin对海马神经元形态发生的影响。此外，我们正在构建不同亚型的神经调节蛋白的表达结构，并将比较它们的亚细胞定位和对海马神经元发育的影响之间的差异。
英文摘要
We are investigating the subcellular localization and effect of overexpressing neuregulin in hippocampal neurons. We observed that neuregulin exists in clusters in hippocampal neurons. We are examining whether these neuregulin clusters associate with specific subcellular compartments. We are also analyzing the effect of overexpressing neuregulin on the morphogenesis of hippocampal neurons. In addition, we are building expressing constructs for different isoforms of neuregulins, and will compare the difference between their subcellular localization and effect on hippocampal neuron development.
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