CTSA Predoctoral T32 at Albert Einstein College of Medicine

摘要 此应用程序旨在继续长期CTSA支持的博士前计划，在临床博士学位 研究（PCI）在阿尔伯特·爱因斯坦医学院（爱因斯坦）。PCI结合专业培训， 准备生物医学科学家了解和欣赏临床和人口的方法 科学，作为研究团队的领导者和成员实践团队科学，并推进 翻译科学学科。PCI利用了爱因斯坦在基础实验室方面的长期成功- 基于研究。PCI与我们的硕士学位授予临床研究培训的独特整合 计划（CRTP），以及我们的要求，即每个学生的研究和指导团队必须“架起一座桥梁”，沿着 翻译鸿沟，"培养多学科团队科学，同时教授方法，以克服 翻译研究的障碍。PCI已（1）授予18名博士学位，（2）12名现有学员，（3）持续 从历史上被边缘化的社区（HMC）招收学员，以及（4） 询问和申请人。爱因斯坦位于纽约州的布朗克斯，这是美国最多样化和最贫穷的城市县。 美国，其集水区在与以下方面有关的健康结果方面存在种族和民族差异： 癌症、心血管疾病和传染病。因为我们的实习生的大部分研究都涉及病人 从我们的集水区的数据和样本，PCI基本上一直在培训学员进行临床和 翻译科学（TS）研究，有意义地有助于我们理解和减轻 不成比例地影响HMC的差异。从我们项目的成功和需求的增加， 我们寻求在下一个资助期内发展PCI，正式强调整合卫生公平性 (HE)我们的培训和确保计划的可持续性。我们将把健康差距研究与 通过与社区和利益相关者的合作，专注于克服高等教育进入我们培训的障碍 我们的同伴CTSA UM1的参与研究模块。我们将加强对下一代的培训 培训生，谁已受到不利影响的COVID-19大流行，通过建立的立场， 学生支持副主任。我们将通过开发PCI特定的F奖来提高可持续性 提交程序的路径。虽然PCI是疾病不可知的，但我们的许多学员都承担了 与我们的集水区高度相关的研究，特别是与传染病，癌症， 脑科学在下一个融资期间，我们寻求利用非分类PCI并开发新的 研究重点领域在传染病，癌症的结果，脑科学，高度整合 资助导师，并提供机会，使额外的疾病特异性T32赠款到PCI，提供 PCI学员资助机会超出了通过此应用程序寻求的四个疾病不可知插槽。 虽然我们的培训方法将保持非分类，但在下一个项目期间，我们将努力强调 这些重点领域根据我们的机构优势，同时应用TS和HE镜头到所有学员的项目。

ABSTRACT This application seeks to continue a longstanding CTSA-supported predoctoral program, the PhD in Clinical Investigation (PCI) at the Albert Einstein College of Medicine (Einstein). PCI combines specialized training to prepare biomedical scientists to understand and appreciate the methodologies of clinical and population science, to practice team science as both leaders and members of research teams, and to advance the discipline of translational science. PCI leverages Einstein's longstanding success in fundamental laboratory- based research. PCI's unique integration with our master's degree-granting Clinical Research Training Program (CRTP), along with our requirement that each student's research and mentoring team must “bridge a translational divide,” fosters multidisciplinary team science while teaching the methodologies to overcome barriers plaguing translational research. PCI has (1) conferred 18 PhDs, (2) 12 current trainees, (3) sustained enrollment of trainees from historically marginalized communities (HMCs), and (4) a dramatic increase in inquiries and applicants. Einstein is located in the Bronx, NY, the most diverse and poorest urban county in the United States, whose catchment area experiences racial and ethnic disparities in health outcomes related to cancer, cardiovascular disease, and infectious diseases. Since much of our trainees' research involves patient data and samples from our catchment area, PCI has essentially been training trainees to conduct clinical and translational science (TS) research that meaningfully contributes to our understanding and mitigation of disparities that disproportionately affect HMCs. Building from our program's success and increased demand, we seek to evolve PCI during the next funding period with formalized emphasis on integrating health equity (HE) into our training and ensuring program sustainability. We will integrate health disparities research with a focus on overcoming barriers to HE into our training though collaboration with the Community and Stakeholder Engagement Research Module of our companion CTSA UM1. We will improve training of the next generation of trainees, who have been unfavorably affected by the COVID-19 pandemic, by establishing the position of Associate Director for Student Support. We will improve sustainability by developing a PCI-specific F-award path to submission program. While the PCI is disease-agnostic, many of our trainees have undertaken research that is highly relevant to our catchment area, particularly in relation to infectious disease, cancer, and brain science. During the next funding period, we seek to leverage the non-categorical PCI and develop new Research Focus Areas in Infectious Disease, Cancer Outcomes, and Brain Sciences, to integrate highly funded mentors and provide the opportunity to bring additional disease-specific T32 grants into PCI, providing PCI trainees funding opportunities beyond the four disease-agnostic slots sought through this application. While our training approach will remain non-categorical, in the next project period we will seek to emphasize these focus areas per our institutional strengths, while applying TS and HE lenses to all trainees' projects.