Simple Automatic Perfusion System for salvage after cardiac arrest

描述(由申请人提供)：体外支持(ECPR)将心脏骤停复苏的存活率从5%提高到30%。体外支持有助于心脏死亡(DCD)后供体器官的挽救。医学研究所的报告指出，抢救DCD器官的创新方法是器官移植的重中之重。然而，ECS很少用于这些应用程序。限制因素是需要一种简单的自动灌流系统，该系统本质上是安全的，可以由辅助医疗人员启动，并且在没有操作员干预的情况下提供全面的支持。MC3在开发这种设备方面具有得天独厚的优势。密歇根大学的研究小组已经证明了ECPR是可行的，并导致30%的健康存活率。同一研究小组已经证明，心脏骤停死亡后的机械器官灌流(DCD-ECS)可以将肝和肾功能恢复到可移植的状态。此外，在移植后，这些DCD-ECS器官甚至比心脏跳动的脑死亡捐赠者的器官更成功。本研究项目的目标是设计和生产一种简单的自动灌流系统(APS)用于体外支持，以方便心脏骤停后捐赠者的心肺复苏和器官挽救。公共卫生相关性本研究项目的目标是设计和生产一种简单的自动灌流系统(APS)，作为心脏骤停时CPR的辅助设备，用于体外支持，并促进心脏骤停后捐赠者的器官回收。ECPR可以将被捕期间的健康存活率从5%提高到30%。抢救心脏骤停捐赠者的器官可以使器官的可获得性增加十倍。

DESCRIPTION (provided by applicant): Extracorporeal support (ECPR) improves survival in resuscitation from cardiac arrest from 5% to 30%. Extracorporeal support facilitates the salvage of donor organs after cardiac death (DCD). The Institute of Medicine report states that innovative methods to salvage DCD organs are the highest priority in organ transplantation. However ECS is rarely used for these applications. The limiting factor is the need for a simple automatic perfusion system which is inherently safe, can be initiated by paramedical personnel, and provides full support without operator intervention. MC3 is uniquely positioned to develop such a device. The research team at the University of Michigan has demonstrated that ECPR is feasible and results in 30% healthy survival. The same team has shown that mechanical organ perfusion after death by cardiac arrest (DCD-ECS) restores liver and kidney function to transplantable status. Moreover, after transplantation these DCD-ECS organs are even more successful than organs from heart-beating brain dead donors. The goal of this research project is to design and produce a simple Automatic Perfusion System (APS) for extracorporeal support to facilitate ECPR and organ salvage from donors after cardiac arrest. PUBLIC HEALTH RELEVANCE The goal of this research project is to design and produce a simple Automatic Perfusion System (APS) for extracorporeal support as an adjunct to CPR in cardiac arrest, and to facilitate organ salvage from donors after cardiac arrest. ECPR can increase healthy survival in arrest from 5% to 30%. Salvaging organs from cardiac arrest donors could increase the availability of organs tenfold.