Investigating the unification of supramolecular and organometallic catalysis for new reaction development

具有良好反应活性， 同时提供类似官能团之间的化学选择性通常与一个 另这些挑战在制备生物学上重要的分子或 修改现有的支架来研究结构活性关系， 高价值底物通常含有具有交叉反应性的官能团。的能力 开发能够进行精确改性的催化剂仍然是一个高度追求的目标， 学术和工业研究。这些议定书的示范是一个重大的胜利， 催化剂设计和合成，导致下一代生物相关化合物 有着救命的功效该提案概述了一项战略， 催化与超分子簇绕过交叉的固有问题， 反应性，并在络合物上实现化学选择性和最终对映选择性转化 分子支架超分子簇具有被证明的赋予独特反应性的能力 在有机和有机金属转化中，通过动态微环境， 得益于大量的非共价相互作用。在这些成功的启发下，研究 该提案中概述的计划提供了两条路径， 我收集的结果。最后，对不对称转化的研究 将揭示超分子簇和有机金属的非共价相互作用 催化剂，产生了动态微环境如何影响催化的独特观点。的 拟议的研究最终寻求开发方法， 和以新的方式修饰结构复杂的医学相关分子 同时也扩展了科学知识。

The development of organometallic catalysts that exhibit good reactivity while concurrently offering chemoselectivity between similar functional groups are often at odds with one another. These challenges culminate when preparing biologically important molecules or modifying existing scaffolds to investigate structure activity relationships as these high-value substrates often contain functional groups with cross reactivity. The ability to develop catalysts capable of performing precise modifications remains a highly sought after goal in academic and industrial research. Demonstration of these protocols represents a major triumph in catalyst design and synthesis which leads to the next generation of biologically relevant compounds with life-saving properties. This proposal outlines a strategy that combines organometallic catalysis with supramolecular clusters to circumnavigate the inherent issues of cross reactivity and achieve chemoselective and ultimately enantioselective transformation on complex molecular scaffolds. Supramolecular clusters have a demonstrated ability to endow unique reactivity in organic and organometallic transformations through a dynamic microenvironment that benefits from numerous non-covalent interactions. Inspired by these successes, the research program outlined in this proposal offers two paths which build from promising initial results I have gathered. Ultimately, the investigation of enantioselective transformation will reveal the non-covalent interactions of a supramolecular cluster and organometallic catalysts, yielding a unique view of how dynamic microenvironments influence catalysis. The proposed research ultimately seeks to develop methods that will facilitate the preparation and modification of structurally complex medicinally relevant molecules in a novel way concomitantly expanding scientific knowledge.