Mechanistic-based biomarkers of abusive alcohol consumption

项目摘要 过度饮酒(Eau)正逐渐被认为是一个新出现的与健康有关的问题。 从战斗归来的退伍军人中。有必要提高警惕并采取行动，以确定 并为这些处于危险中的退伍军人提供咨询。不幸的是，我们缺乏可靠的诊断测试来检测 危险的饮酒水平。这样的测试对于筛选和照顾退伍军人是不可或缺的 过度饮酒。我们推测，几种新的血清和尿液标志物基于 酒精对免疫细胞的影响可作为预测EAU的生物标志物。为了测试这一点 假设，我们计划追求以下具体目标。具体目标1.确定效果 使用系统生物学并通过检测、识别和比较 这些新靶点的相对数量，并评估它们作为潜在的生物标记物和特定的目标 #2.确定这些生物标志物对酒精相关健康后果的预测能力。 如果成功，该项目的结果将彻底改变退伍军人的筛查方法 过度饮酒。

Project Summary Excessive alcohol use (EAU) is becoming recognized as an emerging health-related problem especially among veterans returning from combats. There is a need for increased vigilance and action to identify and counsel these at-risk veterans. Unfortunately, we lack the reliable diagnostic tests to detect the dangerous levels of drinking. Such tests would be indispensable for screening and care for veterans with excessive alcohol use. We hypothesize that several novel serum and urine markers based on the effect of alcohol on immune cells can be used as the predictive biomarkers for EAU. To test this hypothesis, we plan to pursue the following specific aims. SPECIFIC AIM # 1. To determine the effect of EAU on organ systems using system biology and by detecting, identifying, and comparing the relative quantity of these novel targets and evaluate these as potential biomarkers and SPECIFIC AIM # 2. To determine the predictive capacity of these biomarkers for alcohol-related health consequences. If successful, the results from this project will revolutionize the screening methods for veterans with excessive alcohol use.