2/2 CCNY-MSKCC Partnership for Cancer Research, Education and Community Outreach

CCNY-MSKCC合作伙伴关系成功地创建了互惠互利的跨机构合作 这强调了跨翻译连续体的研究，为 吸引少数族裔和低收入学生投身癌症研究事业，并建立社区 开展语言和文化响应的社区参与研究的网络和资源 在不同的高危人群中。在过去的五年里，发展了一些特别有优势的领域， 包括：1)CCNY工程师和计算机科学家与临床医生和成像人员之间的丰富合作 MSKCC的专家开发创新的解决方案来改善癌症护理，以及2)可持续的、可转换的 健康差距研究和活动，直接惠及纽约服务不足的社区，并为 在以下方面作为国家典范：a)筛查/确定对以下方面影响极大的癌症风险因素 少数群体；b)获得和成功完成治疗的社会经济决定因素；c)政策 变化。与这些重点领域一致，我们提出了两个完整的项目，重点是：1)肿瘤 预测肿瘤休眠和再激活的集成模型，并测试这些模型在 不同种族的细胞系，例如，对非裔美国妇女和 2)研究ATM在免疫球蛋白基因多样性和基因组稳定性中的作用。两个建议 试点项目包括：1)使用重水标记的拉曼光谱和多光子显微镜，以允许 早期发现乳腺癌亚型，包括三阴性癌和2)机械性进展 加强骨肿瘤药物输送的干预措施。新的创新合作伙伴关系组成部分包括：1) 发展语言文化共享性资源核心；2)形成 设计健康差距工作组；以及3)新的教育方案，包括 未来计划和医学翻译和口译证书。合作伙伴关系的具体目标是 到：1)继续在健康差距、生物医学方面发展杰出的癌症研究计划 工程学、计算机科学/医学成像、癌细胞生物学和免疫学 翻译研究连续体；2)与不同的社区合作，开展和促进创新 癌症差异研究，以及外展、教育、降低风险和导航活动，以定义和 解决癌症差异，目标是改善广大医疗服务不足的地方和地区的癌症护理 国家社区；3)继续发展和扩大教育机会，以强有力的翻译 癌症研究环境，吸引和留住对癌症研究感兴趣的学生(特别是少数族裔 和低收入学生)；这些机会将因教育机会而增加并增加 指导和支持；以及4)扩展和整合所需的人员、资源和环境 各机构之间的科学协作，并影响支持这一目标的机构政策。

The CCNY-MSKCC Partnership has successfully created a mutually beneficial, cross-institutional collaboration that has emphasized research across the translational continuum, the creation of an education pipeline for attracting minority and low-income students to careers in cancer research, and the establishment of community networks and resources for conducting linguistically and culturally-responsive community engaged research among diverse, at-risk populations. Over the last five years, areas of particular strength have been developed, including: 1) rich collaborations between engineers and computer scientists at CCNY and clinicians and imaging experts at MSKCC to develop innovative solutions to improve cancer care, and 2) sustainable, translational health disparities research and activities that directly benefit underserved communities in New York, and serve as national models in terms of: a) screening / identification of cancer risk factors that disproportionately affect minorities; b) socioeconomic determinants of access to, and successful completion of, treatment; and c) policy change. Consistent with these areas of emphases, we propose two full projects that focus on: 1) Tumor ensemble models to predict tumor dormancy and reactivation and testing how these models perform across various ethnic cell lines, e.g., triple negative tumors that disproportionately affect African American women and 2) Characterizing the Role of ATM in Immunoglobulin Gene Diversification and Genome Stability. Two proposed pilot projects include: 1) Raman spectroscopy with heavy water labeling and multiphoton microscopy to allow early detection of breast cancer subtypes, including triple negative cancers and 2) Development of Mechanical Interventions to Enhance Drug Delivery to Bone Tumors. New innovative Partnership components include: 1) development of the Linguistic and Cultural Responsiveness Shared Resource Core; 2) formation of the Engineering Health Disparities working group; and 3) new educational programs including the Scholars for the Future program and the Certificate for Medical Translation and Interpretation. The Partnership specific aims are to: 1) Continue to develop outstanding cancer research programs in health disparities, biomedical engineering, computer science / medical imaging, cancer cell biology, and immunology along the Translational Research Continuum; 2) collaborate with diverse communities to conduct and facilitate trailblazing cancer disparities research, and outreach, education, risk reduction, and navigation activities to define and address cancer disparities, with the goal of improving cancer care in the large, medically underserved local and national communities; 3) continue to develop and expand educational opportunities in a robust translational cancer research environment to attract and retain students interested in cancer research (particularly minority and low income students); these opportunities will be enhanced by educational opportunities and increased mentorship and support; and 4) expand and integrate the personnel, resources, and environment needed for scientific collaboration across institutions and influence institutional policies in support of this objective.