Wireless Sensors for Functional MRI of Brain Seizures

项目摘要 这个NIH K01指导研究项目的中心目标是开发一种新型的无线通信系统。 用于脑癫痫发作的直接功能性磁共振成像（fMRI）的微电子传感器。fMRI具有 在过去的二十年中，作为一种重要的非侵入性诊断和监测工具出现， 神经病理学病症和脑损伤。然而，它依赖于血氧水平依赖性（BOLD） 信号，主要来源于神经血管，是神经活动的基本间接表现。 这就排除了抑制性和兴奋性神经活动之间的区别，有假阳性和假阳性的风险。 在诊断和监测脑癫痫发作方面呈阴性。在这个项目中，指导调查员将 联合收割机结合了他在微电子探针方面的专业知识，用于记录神经活动，并将其与联合收割机结合起来， 主办机构的神经成像能力，开发无线MRI传感器，以独特和具体 解决啮齿动物病理性脑模式的时间和跨区域表现的问题 癫痫模型这种新形式的大脑成像将允许获得癫痫发作的直接读数 使用MRI，利用其三维编码能力来研究异常放电模式和神经 大脑功能障碍这里提出的研究代表了一个新的和创新的第一步， 神经科学和神经学研究领域，用于治疗脑部疾病。的新颖的方法 这里提出的指导科学家将广泛适用于神经生物学的问题，并将 改变神经科学家研究神经病理性疾病中大脑整合功能的能力。 该方法还将有助于在诊断医学中建立一条新的道路， 有源器件驱动MRI对比度的变化类似于常规化学造影剂，并且可以 功能性磁共振成像的细胞生理学方面的报告。Aviad Hai博士将担任首席研究员 为这个项目。海博士是一位神经生物学工程师，专注于开发和应用新的 用于神经成像和大脑记录的传感器。海博士在开发过程中做出了几项关键贡献 新的诊断成像剂，用于研究在啮齿动物大脑中使用MRI的生理过程， 以及用于记录和刺激大脑活动的纳米工程探针的开发。他深入的 在微电子工程和成像部分的专业知识和出版的贡献， 这个项目使他处于领导这个高度多学科指导项目的自然位置。海博士将指导 微电子制造的努力，在体外和动物体内验证，所有这些都在他的范围内， 专业知识

Project Summary The central aim of this NIH K01 mentored research project is the development of a new type of wireless microelectronic sensors for direct functional magnetic resonance imaging (fMRI) of brain seizures. fMRI has emerged in the past two decades as a prominent tool for noninvasive diagnosis and monitoring of neuropathological disorders and brain injury. However, it relies on blood oxygen level-dependent (BOLD) signal, which is mainly of neurovascular origin and is a fundamentally indirect manifestation of neural activity. This precludes the distinction between inhibitory and excitatory neural activity, risking false positives and false negatives in the diagnosis and monitoring of brain seizures. In this project, the mentored investigator will combine his expertise in microelectronic probes for the recording of neural activity, and combine them with neuroimaging capabilities of the host institution, to develop wireless MRI sensors to uniquely and specifically address questions of temporal and cross-regional manifestations of pathological brain patterns in rodent models of epilepsy. This new form of brain imaging will allow for the acquisition of direct readouts of seizures using MRI, employing its three-dimensional encoding capabilities to study abnormal firing patterns and neural dysfunction across the brain. The research proposed here represents an initial step in a new and innovative field for neuroscience and neurological research for the treatment of brain diseases. The novel methods propose here by the mentored scientist will be broadly applicable to problems in neurobiology, and will transform the ability of neuroscientists to study integrative functions of the brain in neuropathological disorders. The approach will also help to establish a new path in diagnostic medicine whereby responsive microfabricated active devices drive the change in MRI contrast similarly to conventional chemical contrast agents, and can report on aspects of cellular physiology for functional MRI. Aviad Hai, PhD, will serve as principal investigator for this project. Dr. Hai is a neurobiological engineer that focuses on the development and application of novel sensors for neuroimaging and brain recording.. Dr. Hai has made several key contributions in the development of new diagnostic imaging agents for studying physiological processes in the brain using MRI in rodents, as well as the development nano-engineered probes for recording and stimulation of brain activity. His extensive expertise and published contributions in both the microelectronic engineering and imaging portions of the project put him at a natural position of leading this highly multidisciplinary mentored project. Dr. Hai will direct efforts of microelectronic fabrication, in-vitro and in-vivo validation in animals, all of which are within his expertise.