Joint Biology Consortium Resource-based Center

项目总结/摘要-总体 打破转化研究的障碍是找到治疗炎症性关节炎新方法的关键 在成人和儿童。因此，我们提出了联合生物学联盟（JBC），一个共享的基础设施 总部设在布里格姆妇女医院，波士顿儿童医院和布罗德研究所，以加快 一个以关节炎为重点的研究社区在美国和国外的17个研究中心的工作。三 围绕JBC成员的共同需求设计的核心将提高现有研究的效率， 促进创新，培养初级调查员。 1.行政核心是JBC的组织核心，协调业务并培养 JBC研究网络的科学潜力。JBC协同会议促进科学交流， JBC门户网站促进了沟通和服务交付。JBC浓缩 该计划结合了获奖导师的创新，通过赠款支持JBC青年调查员 目标审查，一个新的指导方案，和小额赠款，使利用JBC的核心服务。 2.人类生物样本核心为成人和儿童生物样本提供“一站式购物”， 关节炎研究基于网络的搜索和有针对性的诊所招募将改变多种不同的 将BWH和Children's的资源整合到一个统一的生物标本和相关临床和遗传学管道中 数据 3.细胞系统核心为关节炎研究提供了资源和专业知识密集型工具。关键 服务包括集中的人类样本处理，CyTOF，单细胞和低输入RNA-seq，以及 创新的HoxB 8技术核心，用于临床前模型细胞的生成和CRISPR/Cas9操作， 包括嗜中性粒细胞、单核细胞和破骨细胞。 由致力于关节炎研究人员带头主任彼得Nigrovic博士和副主任博士。 伊丽莎白·卡尔森，JBC将在一个包容性和高度协作的高级网络中促进创新 和初级研究人员，领导联合生物学联盟成为转化研究的引擎， 成人和小儿关节炎。

PROJECT SUMMARY/ABSTRACT - Overall Breaking down barriers to translational research is the key to finding new approaches to inflammatory arthritis in adults and children. We therefore propose the Joint Biology Consortium (JBC), a shared infrastructure based at the Brigham and Women's Hospital, Boston Children's Hospital, and the Broad Institute to accelerate the work of an arthritis-focused Research Community at 17 research centers in the US and abroad. Three Cores designed around the shared needs of JBC members will enhance the efficiency of existing studies, facilitate innovation, and foster junior investigators. 1. The Administrative Core is the organizational heart of the JBC, coordinating operations and cultivating the scientific potential of the JBC research network. The JBC Synergy Meeting promotes scientific interchange and collaboration, while the JBC Web Portal facilitates communication and service delivery. The JBC Enrichment Program, incorporating innovations from award-winning mentors, supports JBC Young Investigators via grant aims review, a novel mentoring program, and microgrants to enable utilization of JBC core service. 2. The Human Biosamples Core provides “one stop shopping” for adult and pediatric biospecimens essential to arthritis research. Web-based searches and targeted in-clinic recruitment will transform multiple distinct resources at BWH and Children's into a unified pipeline for biospecimens and associated clinical and genetic data. 3. The Cellular Systems Core provides resource- and expertise-intensive tools for arthritis research. Key services include centralized human sample processing, CyTOF, single-cell and low-input RNA-seq, and an innovative HoxB8 technology core for generation and CRISPR/Cas9 manipulation of pre-clinical model cells, including neutrophils, monocytes, and osteoclasts. Spearheaded by committed arthritis researchers Director Dr. Peter Nigrovic and Associate Director Dr. Elizabeth Karlson, the JBC will spur innovation within an inclusive and highly collaborative network of senior and junior investigators, leading the Joint Biology Consortium to become an engine of translational research in adult and pediatric arthritis.