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High-throughput screening for small molecules demonstrating toxicity against human neuroendocrine tumor cell lines

High-throughput screening for small molecules demonstrating toxicity against human neuroendocrine tumor cell lines
高通量筛选对人类神经内分泌肿瘤细胞系具有毒性的小分子
批准号：
10005001
负责人：
Matthew Hall
金额：
$13.27万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10005001
关键词：
AffectCancer cell lineCell LineClinicalHumanIncidenceLibrariesLung NeoplasmsLung Neuroendocrine NeoplasmMalignant NeoplasmsMalignant neoplasm of lungNeuroendocrine CellNeuroendocrine TumorsNuclear Pore ComplexPharmaceutical PreparationsReportingSubgroupToxic effectTumor Cell LineUnited Statescancer typeeffective therapyhigh throughput screeningscreeningsmall moleculesmall molecule librariestumor

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中文摘要
翻译
肺网是由神经内分泌细胞引起的一组不同类型的恶性肿瘤。根据不同等级的不同，网络可分为四个亚型。在美国，肺网的年发病率在过去30年中大幅增加，突显出对这种类型的肿瘤进行有效治疗的必要性日益增加。 在本报告所述期间，项目组根据NPC和MIPE图书馆中的4,000多种化合物选择和筛选了几条肺网。活性化合物是精心挑选出来的，用于对更大范围的癌细胞系进行扩大毒性筛选，那些具有诱人活性特征的化合物目前正在进行高级表征。
英文摘要
Lung NETs comprise a heterogeneous subgroup of malignancies that arise from neuroendocrine cells. NET can be classified into four subtypes according to their differentiation of grade. In the United States, the annual incidence of lung NETs has substantially increased over the past 30 years, highlighting an increased need for an effective therapy against this type of tumors. During this reporting period, the project team selected and screened several lung NET lines against more than 4,000 compounds in the NPC and MIPE libraries. Active compounds were cherry-picked for expanded toxicity screening against a larger panel of cancer cell lines, and those hits with attractive activity profiles are currently undergoing advanced characterization.
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