California National Primate Research Center (CNPRC) - NIA Supplement

概述 摘要 位于加州大学戴维斯分校的加州国家灵长类动物研究中心（CNPRC）， 请求对基本业务赠款#P51-OD 011107提供补充资金。目前，在第58年的运作， CNPRC为全国范围内NIH支持的研究者和行业合作伙伴提供服务。从成立 通过本年度，CNPRC一直高度响应研究界提供高 优质的动物，设施，工具和服务，由核心科学家的知识基础设施驱动， 我们的使命服务：“通过支持特殊的非人类， 灵长类动物研究计划”。所要求的补充资金符合以下具体目标：（1） 进行最先进的研究，并在科学上有助于理解和治疗人类疾病。 疾病与非人灵长类动物模型在整个年龄范围，（2）提供特殊的非人灵长类动物 为地方、地区和国家层面的研究人员提供专业知识和服务，以推进NIH支持的 卓越的研究，（3）指导和培养下一代的翻译研究人员与非人类 灵长类专业知识，（4）确保负责任的研究和动物护理行为的最高标准，以及5） 稳定和扩大国家免疫局资助的老年恒河猴群体。我们将继续强调团队 科学旨在解决人类一生中的主要健康问题，目标是超越传统的 跨学科的努力，以真正的研究问题正在解决的趋同。在此P51修订版中， 需要支持扩大我们的国家老龄化研究所（NIA）资助的老年恒河猴群体。 该计划是我们正在进行的研究工作的一部分，重点是整个生命周期的健康。我们致力 提供广泛的研究机会，最大限度地利用非人灵长类动物模型， 在与年龄有关的疾病和机能衰退方面，人类健康。

OVERVIEW ABSTRACT The California National Primate Research Center (CNPRC), located at the University of California, Davis, requests supplemental funds to the base operating grant #P51-OD011107. Currently in the 58th year of operation, the CNPRC serves a range of NIH-supported investigators and industry partners nationwide. From inception through the current year, the CNPRC has been highly responsive to the research community by providing high quality animals, facilities, tools, and services driven by the intellectual infrastructure of the Core Scientists in the service of our Mission: “To improve human health and quality of life through support of exceptional nonhuman primate research programs”. The supplemental funds requested fit within the following Specific Aims: (1) Conduct state-of-the-art research and scientifically contribute to the understanding and treatment of human disease with nonhuman primate models across the age spectrum, (2) Provide exceptional nonhuman primate expertise and services to investigators at the local, regional, and national levels to advance NIH-supported research excellence, (3) Mentor and train the next generation of translational investigators with nonhuman primate expertise, (4) Ensure the highest standards of responsible conduct of research and animal care, and 5) Stabilize and expand the NIA-funded colony of aged rhesus monkeys. We will continue to emphasize team science aimed at major human health problems across the lifespan, with the goal of moving beyond traditional interdisciplinary efforts to true convergence on the research problems being addressed. In this P51 Revision, support is requested to expand our National Institute on Aging (NIA) funded colony of aged rhesus monkeys. This program is integral to our ongoing research efforts focused on health across the lifespan. We are committed to providing a wide range of research opportunities that maximize use of the nonhuman primate model to improve human health with respect to age-associated diseases and declining function.