Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心摘要/摘要 子宫内膜癌SPORE计划的生物统计学和生物信息学核心将支持 项目，并协助其他核心，在临床和临床前实验的设计和解释， 以及数据的获取和管理。核心服务对于项目的临床试验至关重要， 以及他们对基因表达谱（GEP）的高维方法的使用，下一代 测序（NGS）和反相蛋白质阵列（RPPA）。核心将结合声音实验 每个项目内的设计原则，具体到正在解决的科学问题。每个项目将 提供量身定制的分析，同时提供适当的，有时是新颖的生物统计学或 生物信息学方法核心领导人将与项目调查人员合作，确定量化措施， 可用于检验研究假设，包括确定样本量，以确保有足够的把握度， 问题研究核心的领导人将定期与项目调查人员讨论设计， 开展研究项目，评估分析结果，讨论潜在的新研究举措， 在SPORE内的方向，并促进研究结果的出版。核心和项目之间的相互作用， 以及其他一体化，将通过一个可上网查阅的有关信息数据库加以促进 每个项目，由核心开发和维护。 生物统计学和生物信息学核心的主要目标是： 1.在实验室实验的设计和实施方面提供生物统计学和生物信息学专业知识， 本申请中提出的研究所产生的临床试验。 2.对根据SPORE收集的所有数据进行生物统计学和生物信息学分析和解释 项目，职业发展计划项目，发展项目和其他核心。 3.与所有项目研究人员合作并协助他们发表科学成果。 4.开发并维护一个可通过网络访问的、针对SPORE的所有项目相关信息数据库。

Biostatistics and Bioinformatics Core SUMMARY/ABSTRACT The Biostatistics and Bioinformatics Core for the Endometrial Cancer SPORE program will support the Projects, and assist the other Cores, in the design and interpretation of clinical and preclinical experiments, and the acquisition and management of data. Core services will be critical for the clinical trials of the Projects, and their use of high-dimensional methodologies of gene expression profiling (GEP), next-generation sequencing (NGS) and Reverse Phase Protein Arrays (RPPAs). The Core will incorporate sound experimental design principles within each Project, specific to the scientific issues being addressed. Each Project will be provided with tailored analyses, accompanied by appropriate and sometimes novel biostatistical or bioinformatics methods. Core leaders will work with Project investigators to identify quantitative measures that can be used to test study hypotheses, including determining sample sizes to ensure sufficient power for the studies. The leaders of the Core will confer regularly with Project investigators to discuss the design and conduct of research projects, evaluate results of analyses, discuss potential new research initiatives and directions within the SPORE, and promote publication of findings. Interactions between the Core and Projects, as well as other integration, will be facilitated by a web-accessible database of relevant information generated by each Project, to be developed and maintained by the Core. The main objectives of the Biostatistics and Bioinformatics Core are to: 1. Provide biostatistics and bioinformatics expertise in the design and conduct of laboratory experiments and clinical trials arising from the research proposed in this application. 2. Provide biostatistics and bioinformatics analysis and interpretation of all data collected under the SPORE Projects, Career Enhancement Program Projects, Developmental Projects, and other Cores. 3. Collaborate and assist all project investigators with the publication of scientific results. 4. Develop and maintain a web-accessible, SPORE-specific database of relevant information for all Projects.