CENTRALIZED OMICS RESOURCE (CORE)YEAR 4

集中式Omics资源(CORE)技术是一项始于2015年的多项奖励不确定交付不确定数量(IDIQ)，并为全基因组测序和其他组学措施提供IDIQ合同奖励，包括DNA甲基化、RNA表达模式和代谢图谱。CORE与NHLBI的TOPMed计划一起，寻求发现影响疾病风险的因素和变量，识别疾病的亚类型，并开发更有针对性和个性化的治疗方法。通过同行评审选择研究和建议的研究设计和组学，并将批准的样本提供给11个选定的组学中心之一；产生的原始和处理数据使用TOPMed批准和设计的管道进行处理，并与原始研究、在TOPMed领域工作组工作的TOPMed PI共享，也可供NHLBI指导的数据储存库与批准的研究人员共享。TOPMed研究包括多个非欧洲人(代表性不足的人群)以及包括或完全是女性的研究。

Centralized Omics REsource (CORE) Technologies is a multiple award Indefinite Delivery Indefinite Quantity (IDIQ) begun in 2015 and provides IDIQ contract awards for whole genome sequencing and other omics measures, including DNA methylation, RNA expression patterns, and metabolic profiling. CORE, in conjunction with NHLBI's overarching TOPMed Program, seeks to discover factors and variants that influence disease risk, identify subtypes of disease, and develop more targeted and personalized treatments. Studies and proposed study designs and omics are selected via peer review and are approved samples supplied to one of eleven selected omics centers; the resulting raw and processed data is processed using TOPMed approved and designed pipelines and shared with originating studies, TOPMed PIs working in TOPMed domain working groups, and are also made available to NHLBI directed data repositories for sharing with approved investigators. TOPMed studies include multiple non-European (underrepresented populations) as well as studies that include or are entirely female.