TOPIC 360: A SIMPLE END-TO-END SYSTEM FOR SERIAL CELL SORTING AND MANIPULATION USING A SINGLE CONTAINER- MOONSHOT

化疗可以控制，但很少能治愈转移性癌症。值得注意的是，现代免疫疗法，包括基于细胞的疗法，已经治愈了转移性黑色素瘤和其他类型的癌症。总的来说，所有细胞疗法的一个主要挑战是需要开发具有成本效益和效率的制造和交付能力。我们最近通过应用靶向微泡建立了一种创新的细胞分离技术，这种微泡具有许多有趣的特性，非常适合于批量细胞分离。在第一阶段，我们已经证明了制造一种简单且经济高效的系统来丰富需要多个标记来识别的感兴趣细胞的可行性。在第二阶段，我们将继续开发一个封闭式自动化系统，只使用一个容器集成在cGMP环境中进行细胞分离、扩增和操作。

Chemotherapy may control but rarely cure metastatic cancers. Remarkably, modern immunotherapies, including cell-based therapies, have cured metastatic melanomas and other types of cancers. A major challenge for all cell therapies in general is the need to develop cost-effective and efficient manufacturing and delivery capabilities. We have recently established an innovative cell isolation technology by applying targeted microbubbles, which have a number of interesting properties that are ideal for bulk cell isolation. In Phase I, we have demonstrated the feasibility for manufacturing a simple and cost-efficient system to enrich cells of interest that require multiple markers to identify. In Phase II, we will continue developing a closed automated system using only a single container to be integrated in a cGMP environment for cell isolation, expansion and manipulation.