Conference: Stem Cells, Cell Therapy and Bioengineering in Lung Biology and Diseases 2023

第十届干细胞、细胞治疗和生物工程肺部生物学和疾病会议将于2023年7月17日至20日在伯灵顿的佛蒙特大学举行，自2005年两年一度的系列会议开始以来，所有会议都在这里举行。这次会议填补了干细胞、细胞疗法、肺部生物学和生物工程等快速发展领域的重要空白。除了促使国际领导人以及未来的研究人员和受训人员进行广泛的讨论和辩论外，一项重要的成果是一套供调查人员和资助机构使用的基础和转化性研究的指导方针。与往年一样，初级调查员、受训人员和来自任职人数不足群体的调查员将优先参加会议组织、口头陈述、主持活动、讨论和宣传会议。2023年，将推出一项令人兴奋的高中STEM体验，通过为参与者提供机会与来自世界各地的科学教师和受训人员接触，并进一步获得最先进的科学技术经验来培养下一代科学家。使用干细胞或生物工程组织修复和再生患病的肺是各种肺部疾病和危重疾病令人兴奋的潜在治疗方法。在过去的十年中，越来越多的临床前模型证据表明，非正常驻留在肺中的细胞，特别是间充质基质细胞(MSCs)可以用于调节损伤后的免疫反应，但将这些有希望的发现转化到临床上一直存在挑战。与此同时，生物工程研究激增，研究使用人工和无细胞肺基质作为三维肺或呼吸道再生的支架，最近一些尝试在大型动物模型中进行移植。将这些研究与那些利用干细胞、诱导多能干细胞衍生物和/或细胞疗法的研究相结合，是一个很有前途的快速发展的研究领域。与这些研究进一步平行的是，人们对内源性肺干细胞和/或祖细胞在肺发育过程中以及在肺损伤后的正常和病理修复和重塑过程中产生和分化的分子和细胞事件的了解显著增加。在2023年会议上，科学研讨会被选为反映该领域最尖端进展的会议，将包括侧重于组学与功能的整合、细胞外基质的作用以及免疫细胞对肺修复和再生的影响的会议。这些前沿的基础科学和翻译科学研究正在迅速加强对肺修复和再生的基本理解，计划中的会议将继续帮助形成进一步的进展。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The 10th Stem Cells, Cell Therapy and Bioengineering in Lung Biology and Diseases Conference will be held 17-20 July 2023, at the University of Vermont in Burlington, which has been the venue of all of the conferences since the biannual series began in 2005. The conference fills an important niche in the rapidly moving fields of stem cells, cell therapies, lung biology, and bioengineering. In addition to stimulating extensive discussion and debate by international leaders and up and coming investigators and trainees, an important deliverable is a set of guidelines for basic and translational research to be utilized by both investigators and funding agencies. As in previous years, junior investigators, trainees, and investigators from underrepresented groups will be prioritized for inclusion in conference organization, oral presentations, chairing activities, discussions, and poster sessions. In 2023, an exciting new High School STEM Experience will be introduced to foster the next generation of scientists by providing on opportunity for participants to engage with scientific faculty and trainees from around the world and further gain experience with state-of-the-art scientific techniques.Repair and regeneration of a diseased lung with stem cells or bioengineered tissues are exciting potential therapeutic approaches for a variety of lung diseases and critical illnesses. Over the past decade, increasing evidence in preclinical models suggests that cells which are not normally resident in the lung, notably mesenchymal stromal cells (MSCs) can be utilized to modulate immune responses after injury, but there have been challenges in translating these promising findings to the clinic. In parallel, there has been a surge in bioengineering studies investigating use of artificial and acellular lung matrices as scaffolds for three-dimensional lung or airway regeneration, with some recent attempts of transplantation in large animal models. The combination of these studies with those utilizing stem cells, induced pluripotent stem cell derivatives, and/or cell therapies is a promising and rapidly developing research area. These studies have been further paralleled by significant increases in understanding the molecular and cellular events by which endogenous lung stem and/or progenitor cells arise and differentiate during lung development and in normal and pathologic repair and remodeling after lung injury. For the 2023 conference, scientific symposia have been chosen to reflect the most cutting-edge advances in the field and will include sessions focusing on the integration of omics with function, the role of the extracellular matrix, and the influence of immune cells on lung repair and regeneration. These cutting edge basic and translational science studies are rapidly enhancing fundamental understanding of lung repair and regeneration and the planned conference will continue to help shape further progress.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.