Conference: Stem Cells, Cell Therapy and Bioengineering in Lung Biology and Diseases 2023

第10届干细胞，细胞治疗和生物工程在肺部生物学和疾病会议将于2023年7月17日至20日在伯灵顿佛蒙特大学举行，自2005年开始的两年一次系列会议以来，该会议一直是所有会议的举办地。该会议填补了干细胞，细胞疗法，肺生物学和生物工程等快速发展领域的重要利基。除了激发国际领导人和即将到来的研究人员和学员进行广泛的讨论和辩论外，一个重要的成果是一套供研究人员和资助机构使用的基础和转化研究指南。与往年一样，将优先考虑将初级调查员、受训人员和代表性不足群体的调查员纳入会议组织、口头报告、主持活动、讨论和海报会议。在2023年，一个令人兴奋的新的高中STEM经验将被引入，以培养下一代科学家，为参与者提供机会，与来自世界各地的科学教师和学员接触，并进一步获得与国家的经验，用干细胞或生物工程组织修复和再生病变的肺是令人兴奋的各种肺的潜在治疗方法。疾病和重大疾病。在过去的十年中，临床前模型中越来越多的证据表明，通常不驻留在肺中的细胞，特别是间充质基质细胞（MSC）可用于调节损伤后的免疫反应，但将这些有希望的发现转化为临床存在挑战。与此同时，生物工程研究也在激增，研究使用人工和脱细胞肺基质作为三维肺或气道再生的支架，最近尝试在大型动物模型中进行移植。将这些研究与利用干细胞、诱导多能干细胞衍生物和/或细胞疗法的研究相结合是一个有前途和快速发展的研究领域。这些研究进一步证实了对内源性肺干细胞和/或祖细胞在肺发育过程中产生和分化以及肺损伤后正常和病理修复和重塑的分子和细胞事件的理解。对于2023年的会议，科学研讨会被选择来反映该领域最前沿的进展，并将包括专注于组学与功能的整合，细胞外基质的作用以及免疫细胞对肺修复和再生的影响的会议。这些前沿的基础和转化科学研究正在迅速提高对肺修复和再生的基本理解，计划中的会议将继续帮助塑造进一步的进展。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The 10th Stem Cells, Cell Therapy and Bioengineering in Lung Biology and Diseases Conference will be held 17-20 July 2023, at the University of Vermont in Burlington, which has been the venue of all of the conferences since the biannual series began in 2005. The conference fills an important niche in the rapidly moving fields of stem cells, cell therapies, lung biology, and bioengineering. In addition to stimulating extensive discussion and debate by international leaders and up and coming investigators and trainees, an important deliverable is a set of guidelines for basic and translational research to be utilized by both investigators and funding agencies. As in previous years, junior investigators, trainees, and investigators from underrepresented groups will be prioritized for inclusion in conference organization, oral presentations, chairing activities, discussions, and poster sessions. In 2023, an exciting new High School STEM Experience will be introduced to foster the next generation of scientists by providing on opportunity for participants to engage with scientific faculty and trainees from around the world and further gain experience with state-of-the-art scientific techniques.Repair and regeneration of a diseased lung with stem cells or bioengineered tissues are exciting potential therapeutic approaches for a variety of lung diseases and critical illnesses. Over the past decade, increasing evidence in preclinical models suggests that cells which are not normally resident in the lung, notably mesenchymal stromal cells (MSCs) can be utilized to modulate immune responses after injury, but there have been challenges in translating these promising findings to the clinic. In parallel, there has been a surge in bioengineering studies investigating use of artificial and acellular lung matrices as scaffolds for three-dimensional lung or airway regeneration, with some recent attempts of transplantation in large animal models. The combination of these studies with those utilizing stem cells, induced pluripotent stem cell derivatives, and/or cell therapies is a promising and rapidly developing research area. These studies have been further paralleled by significant increases in understanding the molecular and cellular events by which endogenous lung stem and/or progenitor cells arise and differentiate during lung development and in normal and pathologic repair and remodeling after lung injury. For the 2023 conference, scientific symposia have been chosen to reflect the most cutting-edge advances in the field and will include sessions focusing on the integration of omics with function, the role of the extracellular matrix, and the influence of immune cells on lung repair and regeneration. These cutting edge basic and translational science studies are rapidly enhancing fundamental understanding of lung repair and regeneration and the planned conference will continue to help shape further progress.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.