BASE AWARD FOR USING RODENT BEHAVIORAL MODELS TO IDENTIFY SUBSTANCE ABUSE PHARMACOTHERAPIES

本合同的目的将是提供下列啮齿动物体内试验的测试能力：小鼠运动 活动，大鼠药物辨别，小鼠条件性位置偏爱，和大鼠自我给药。这些型号是 更大的临床前试验体系的一部分，由单独的合同支持，这些合同为化合物的评估提供资金 大鼠脑内自我刺激试验、各种复吸模型的寻药行为，以及灵长类动物 毒品歧视和自我管理模式。

The purpose of this contract will be to provide testing capacity in the following rodent in vivo assays: mouse locomotor activity, rat drug discrimination, mouse conditioned place preference, and rat self-administration. These models are part of a larger pre-clinical testing hierarchy supported by separate contracts that fund the evaluation of compounds in the rat intracranial self-stimulation assay, various models of relapse to drug-seeking behavior, as well as the primate drug discrimination and self-administration models.