TRANSFORM: Translational Research that Adapts New Science FOR Maltreatment prevention

摘要-总体核心 美国每年有数百万儿童和青少年向儿童保护机构报告， 虐待（忽视，身体，性或情感虐待），并经历其他形式的创伤， 如遭受家庭虐待、社区暴力、危及生命的疾病或伤害或突然失去。一个多样化 来自罗切斯特大学和明尼苏达大学的多学科研究小组将与 NICHD创建转化中心（适应新科学的转化研究） 防止虐待），以防止虐待儿童并解决其后遗症。独特的组合 该多研究者中心的能力，即，专业知识、基础设施支持、人力/财政资源，以及 研究/干预战略对于在一个实验室单独工作的一名研究人员来说是不可行的。 基于当前的科学研究方法和临床实践， 与虐待和忽视儿童相关的个人和社会负担，转型将利用 以理论为基础的循证研究和预防性干预措施，以优化儿童的成果。 在这样做的过程中，该中心将应用从虐待儿童中衍生出来的最先进的概念和方法 研究，并利用儿童福利界的许多长期关系，使其 冲击TRANSFORM将采用多学科的翻译方法， 精神病理学框架，建立在遗传学，神经科学，预防和 干预科学，儿童福利和法院系统，以开发创新的国家资源， 学科和专业领域。为了实现其目标，转型将利用两个研究项目 和两个相互信息和综合的核心：社区参与核心，和行政 核心这种“团队科学”模式将具有不同背景的专业人员聚集在一起， 为项目假设提供理论基础的应用科学家， 循证项目的设计师，研究方法学家，他们就适当的 用于测试模型的实验设计，包括将映射到 调解员和主持人，评估结果的分析方法，可以翻译结果的律师 法律的和司法系统，以及儿童服务专业人员和政府利益攸关方，他们将 参与传播活动。转型将由Sheree Toth博士和Dante Cicchetti博士领导， 国际公认的虐待儿童领域的领导者，他们的合作工作几乎跨越了 四十年，为进行开创性的纵向和预防提供了坚实的基础 这将有助于在多个儿童服务系统的广泛参与的研究。

ABSTRACT - OVERALL CORE Each year millions of young children and adolescents in the U.S. are reported to Child Protective agencies for maltreatment (neglect, physical, sexual, or emotional abuse), and experience additional forms of trauma such as exposure to domestic abuse, community violence, life-threatening illness or injury, or sudden loss. A diverse multidisciplinary team of investigators from the Universities of Rochester and Minnesota will partner with the NICHD to create the TRANSFORM Center (Translational Research that Adapts New Science FOR Maltreatment Prevention) to prevent child maltreatment and to address its sequelae. The unique combined capacity of this multi-investigator Center, i.e., the expertise, infrastructure support, human/fiscal resources, and research/intervention strategies would not be feasible for a single investigator working alone in one laboratory. Building on current state-of-the-science research methodologies and clinical practices that address the personal and societal burden associated with child abuse and neglect, TRANSFORM will leverage theoretically-grounded evidence-based research and preventive interventions to optimize outcomes in children. In doing so, the Center will apply the most advanced concepts and methods derived from child maltreatment research, and leverage numerous longstanding relationships within the child welfare community to make its impact. TRANSFORM will use a multidisciplinary translational approach embedded in a developmental psychopathology framework that builds upon discoveries in genetics, neuroscience, prevention and intervention science, child welfare, and court systems to develop an innovative national resource for diverse disciplines and professional arenas. To achieve its objectives, TRANSFORM will utilize two Research Projects and two mutually-informative and integrated Cores: a Community Engagement Core, and an Administrative Core. This `team science' model brings together professionals with different backgrounds including basic and applied scientists who provide the theoretical grounding for project hypotheses, program developers who are the architects of evidence-based programs, research methodologists who advise on the appropriate experimental designs for testing the models, including the constructs and measures that will map onto the mediators and moderators, the analytical methods for evaluating results, attorneys who can translate results into legal and judicial systems, and child-serving professionals and governmental stakeholders who will participate in dissemination activities. TRANSFORM will be led by Drs. Sheree Toth and Dante Cicchetti, internationally-recognized leaders in the field of child maltreatment, whose collaborative work spans almost four decades and provides a solid foundation for conducting groundbreaking longitudinal and prevention research that will contribute to widespread engagement across multiple child-serving systems.