The Role of Glycolysis in Axon Development

轴突的伸展、收缩和再生是能量依赖的过程。ATP是主要的 细胞能量的形式，它是通过氧化磷酸化产生的，在细胞内， 和糖酵解。该项目旨在探索糖酵解在神经元中的作用， 强调轴突发育的形态发生。该项目还涉及以下方面的作用： 糖酵解在轴突对损伤的反应中的作用。在这两种情况下，该项目还旨在确定 编码糖酵解酶的轴突靶向mRNA响应于 细胞外信号和损伤。

Axon extension, retraction and regeneration are energy dependent processes. ATP is the main form of cellular energy and it is generated through oxidative phosphorylation, in the mitochondrion, and glycolysis. This project aims to pioneer investigations into the role of glycolysis in neuronal morphogenesis with emphasis on axon development. The project also addresses the role of glycolysis in the response of axons to injury. In both contexts, the project also aims to determine if axonally targeted mRNAs encoding glycolytic enzymes undergo axonal translation in response to extracellular signals and injury.