Michigan Nutrition Obesity Research Center

摘要/摘要-总体MNORC 密歇根营养肥胖研究中心(MNORC)最初是在2010年获得资助的 支持、整合和加强与肥胖和营养有关的研究 密歇根大学。MNORC的目标是创造一个鼓励和 使临床前、临床和转化性研究领域的研究人员能够集成 先进的表型和数据分析工具，可更全面地定义个人和群体 因饮食中的营养成分或数量而产生的特征。 这将通过提供核心实验室基础设施、教育和培训来实现。 提高研究效率的机会和试点拨款。MNORC扩大了 响应研究界需求的研究基础设施和核心产品 并支持营养和肥胖研究在密歇根大学校园内的扩展。这 突出的是机构投资建立两个新的核心，这两个核心是 求婚。MNORC有102名成员，他们是密歇根大学不同学院的教职员工。这些 教职员工目前控制着每年近2600万美元的营养/肥胖相关资金的直接成本 用于R-奖和来自非NIH来源的资金，以及每年额外的3000万美元 与营养/肥胖相关的F、K、P、T和U补助金。MNORC核心包括管理 核心，负责监督和整合研究、临床和教育职能 中心，包括年度研讨会、系列研讨会、本科生培训、营养师培训、 医科学生、家庭工作人员和营养和肥胖护理领域的研究员 研究；营养、运动和表型测试核心，将提供专业知识 和基础设施，用于对住院患者进行复杂的代谢和神经行为测试 和门诊环境；分子表型核心，将继续支持 靶向和非靶向代谢组学分析以及多组学数据的新倡议 整合；新成立的脂肪组织核心将提供专业知识和技术 对基础和临床生物医学研究人员有兴趣研究脂肪细胞如何 整个身体发育、发挥功能并与其他类型的细胞相互作用；童年 肥胖研究核心将支持专注于翻译研究的研究人员 通过利用学习健康系统和健康信息实现儿童超重/肥胖 密歇根大学的理工学院。MNORC将继续支持重量 将研究整合到非常成功的成人临床减肥中的管理计划 该计划现已扩展到儿童、家庭和寻求怀孕的妇女。 许多调查人员访问通过该程序收集的患者、生物样本和数据 用于他们自己的研究。在下一个资助期，MNORC将继续与 与研究基地一起确定新的支持领域并调整服务选项 符合社会的需要。

Abstract/Summary – Overall MNORC The Michigan Nutrition Obesity Research Center (MNORC) was initially funded in 2010 to support, integrate and enhance research related to obesity and nutrition among the faculty of the University of Michigan. The goal of MNORC is to create an environment to encourage and enable researchers from preclinical, clinical and translational research disciplines to integrate advanced, phenotyping and data analytic tools to more fully define individual and population characteristics that arise in response to dietary nutrient composition or amount. This will be accomplished by providing core laboratory infrastructure, educational and training opportunities and pilot grants to enhance research productivity. The MNORC has expanded the research infrastructure and Core offerings in response to the needs of the research community and has supported the expansion of nutrition and obesity research across the UM campus. This is highlighted by the institutional investment to establish two new cores that are part of this proposal. MNORC has 102 members that are faculty across the various schools at UM. These faculty currently control just under $26M/year of direct costs in nutrition/obesity-related funding for R-awards and funding from non-NIH sources and an additional $30M/year in nutrition/obesity-related F, K, P, T and U grants. The MNORC Cores include the Administrative Core, which will oversee and integrate the research, clinical and education functions of the Center, including an annual symposium, seminar series, training for undergraduates, dieticians, medical students, house staff and fellows in the breadth of nutrition and obesity care and research; the Nutrition, Exercise and phenotype Testing Core, which will provide expertise and infrastructure for sophisticated metabolic and neurobehavioral testing of humans in inpatient and outpatient settings; the Molecular Phenotyping Core, which will continue supporting targeted and untargeted metabolomics profiling as well as new initiatives for multi-omics data integration; the newly established Adipose Tissue Core will provide expertise and technical services to basic and clinical biomedical researchers interested in investigating how adipocytes throughout the body develop, function, and interact with other cell types; the Childhood Obesity Research Core will support investigators focused on translational research in childhood overweight/obesity by leveraging learning health systems and health information technology at the University of Michigan. MNORC will continue to support the Weight Management Program which integrates research into a highly successful adult clinical weight loss program and is now being extended into children, families and women seeking to become pregnant. Numerous investigators access the patients, biosamples and data collected through this program for their own research. Through the next funding period, MNORC will continue to communicate with the research base to identify new areas for support and adjust the service offerings consistent with the needs of the community.