Optimized Multi-Metabolite Edited MRS at 3T

项目总结 磁共振波谱(MRS)可以无创地测量内源性药物的浓度 体内和大脑中的代谢物。浓度较低的代谢物具有较弱的磁共振信号，因此 更难察觉。编辑后的MRS简化了磁共振频谱，因此这些较弱的信号可以更容易地 量化的。然而，通常只编辑一种代谢物，导致多次扫描和更长时间的检查 当目标为多种低浓度代谢物时。该项目涉及开发和 实现了一种高度优化的多重编辑技术，称为sLASER-Hercules，用于 在一次扫描中同时检测多达8种低浓度的大脑代谢物。它的重现性 该方法将在一组成年受试者体内进行严格的评估。此外，基于软件算法的 关于空间分辨密度矩阵模拟和高级统计，将开发用于优化 这种MRS技术的采集参数提高了对特定人群测量的可靠性，可编辑 SLASER-Hercules可检测到的代谢物。该项目产生的技术将改善 编辑的磁共振波谱的效率及其在临床磁共振检查中的适用性，并最终将允许多种假说 从一次扫描中收集的生化测量中进行测试。考生将承担学费和 接受MR物理、MRS采集方法和PULSE编程方面的培训，以成功实施 SLASER-Hercules序列。本项目中提出的培训和研究将在高度集中的情况下进行 支持性的体制环境，有广泛的资源可用于研究和专业支持。 这位候选人将可以使用最先进的磁共振设备，并将由世界各国领导人在米歇尔·奥巴马夫人的指导下。 还有核磁共振。候选人的长期职业目标是将自己确立为独立的早期阶段 具有完整的MRS方法和应用技能的调查员。

PROJECT SUMMARY Magnetic resonance spectroscopy (MRS) can noninvasively measure the concentration of endogenous metabolites in the body and brain. Lower-concentration metabolites have weaker MR signals and therefore are more difficult to detect. Edited MRS simplifies the MR spectrum so that these weaker signals can be more easily quantified. However, usually only a single metabolite is edited, leading to multiple scans and longer examination times when targeting multiple low-concentration metabolites. This project involves the development and implementation of a highly optimized multiplexed editing technique, termed sLASER-HERCULES, for the simultaneous detection of up to 8 low-concentration brain metabolites in a single scan. The reproducibility of this approach will be rigorously assessed in vivo in a cohort of adult subjects. Additionally, software algorithms based on spatially resolved density-matrix simulations and advanced statistics will be developed for optimizing the acquisition parameters of this MRS technique to improve the reliable measurement of specific groups of editable metabolites detectable by sLASER-HERCULES. The technologies generated from this project will improve the efficiency of edited MRS and its applicability to clinical MR exams and will ultimately allow multiple hypotheses to be tested from biochemical measurements collected in a single scan. The candidate will undertake tuition and training in MR physics, MRS acquisition methodology, and pulse programming to successfully implement the sLASER-HERCULES sequence. The training and research proposed in this project will be undertaken in a highly supportive institutional environment, with extensive resources available for research and professional support. The candidate will have access to state-of-the-art MR facilities and will be mentored by world leaders in MRS and MRI. The long-term career objective of the candidate is to establish himself as an independent early stage investigator with a complete repertoire of skills in MRS methodology and applications.