New insights into the role of renal endothelial dysfunction in the pathogenesis of glomerular injury and renal fibrosis

该项目将确定内皮细胞功能异常是否有助于糖尿病和非糖尿病肾病，这是终末期肾病的主要原因。这项研究的结果将使我们能够重新评估内皮细胞在肾脏瘢痕形成中的作用，使我们质疑我们目前治疗和管理慢性肾脏疾病的方法，最终可能有助于设计治疗慢性肾脏疾病的新疗法。

This project will ascertain whether abnormal function of endothelial cells contribute to diabetic and non-diabetic kidney diseases, the leading cause of end-stage kidney disease. The outcome of this study will allow us to reevaluate the role of endothelial cells in kidney scarring, lead us to question our current approaches to the treatment and management of chronic kidney disease and eventually may be helpful for the design of novel therapies to treat chronic kidney diseases.