Pediatric Critical Care Research Network at Children's Hospital of Philadelphia

 描述（由申请人提供）：儿科重症监护医学已发展为基于成人和动物研究外推数据的临床艺术。Eunice Kennedy Shriver国家儿童健康和人类发展研究所（NICHD）开发了一个合作儿科重症监护研究网络（CPCCRN），通过创新，尖端，多学科的临床研究将儿科重症监护从病理生理学基础的艺术转变为循证科学实践。费城儿童医院（CHOP）是2009-2014年期间由贝格博士和Zipper博士领导的杰出CPCCRN临床研究中心。CHOP继续成为CPCCRN临床试验机构的提案有三个组成部分：#1：证明CHOP有能力成为杰出的CPCCRN临床试验机构。CHOP是一家排名第一的儿童医院，拥有全国最大的儿科研究项目之一：联邦奖总额超过1.38亿美元/年，年度预算超过3.29亿美元。CHOP拥有全国最大的儿科医疗保健系统，是全国最大的儿童医院之一，拥有超过500张床位。CHOP的重症监护医学项目是全国最大的项目之一，拥有55张PICU床位，32张CICU床位，每年有4200名住院患者，为临床研究提供了大量多样化的患者基础。CHOP重症监护医学有9名研究人员，20%的工资来自联邦研究基金，在过去3年中有180多篇同行评议的研究出版物，以及国家认可的儿科重症监护临床研究项目。#2：证明CHOP一直是杰出的CPCCRN临床研究中心（2009-2014）。从2009年到2014年，CHOP一直是CPCCRN研究的主要招募中心。贝格博士领导了四项CPCCRN CPR研究; Zipper博士领导了两项CPCCRN药理学研究; Dilbert女士（CHOP CPCCRN研究协调员）领导了一项CPCCRN研究协调员教育和管理计划。具体目标3：提出一个变革性的研究“概念提案”，强调我们在网络中开发和设计高影响力合作协议的能力和优势：一种拯救生命的方法，以提高需要心肺复苏术（CPR）的儿童的生存率。费城儿童医院是CPCCRN的理想临床基地，基于：1）优秀的资源，机构承诺，计划，教师，生产力和未来的机会; 2）CHOP在2009-2014年期间作为CPCCRN临床基地的表现; 3）令人兴奋的“概念提案”证明了我们成为CPCCRN领导者的能力。

 DESCRIPTION (provided by applicant): Pediatric Critical Care Medicine has developed as a clinical art based on extrapolated data from adult and animal studies. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has developed a Collaborative Pediatric Critical Care Research Network (CPCCRN) to transform Pediatric Critical Care from a pathophysiology based art to an evidence based scientific practice through innovative, cutting-edge, multi-disciplinary clinical investigations. The Children's Hospital of Philadelphia (CHOP) has been an outstanding CPCCRN Clinical Site from 2009-2014, led by Drs. Berg and Zipper. This proposal for CHOP to continue to be a CPCCRN site has three components: #1: To demonstrate CHOP's ability to be an outstanding CPCCRN Clinical Site. CHOP is a top ranked children's hospital with one of the largest pediatric research programs in the country: >$138 million/year in total federal awards and an annual budget >$329 million. CHOP has the nation's largest pediatric health care system, and is one of the nation's largest children's hospitals with >500 beds. CHOP's Critical Care Medicine Program is one of the largest in the nation with 55 PICU beds, 32 CICU beds, and 4200 admissions/year, providing a large and diverse patient base for clinical research. CHOP Critical Care Medicine has 9 investigators with =20% salary support from federal research funding, >180 peer-reviewed research publications in the last 3 years, and nationally recognized pediatric critical care clinicl research programs. #2: To demonstrate that CHOP has been an outstanding CPCCRN Clinical Site (2009-2014). From 2009-2014, CHOP has been the leading enrollment site for CPCCRN studies. Dr. Berg has led four CPCCRN CPR studies; Dr. Zipper has led two CPCCRN pharmacology studies; and Ms. Dilbert (CHOP CPCCRN Research Coordinator) has led a CPCCRN research coordinator education and management program. Specific Aim 3: To present a transformative research "concept proposal" that highlights our capabilities and strengths for development and design of high-impact cooperative protocols in the network: a life-saving approach to improve survival among children who need cardiopulmonary resuscitation (CPR). The Children's Hospital of Philadelphia is an ideal Clinical Site for CPCCRN, based on: 1) the outstanding resources, institutional commitment, programs, faculty, productivity, and future opportunities; 2) CHOP's performance as an outstanding CPCCRN Clinical Site from 2009-2014; and 3) the exciting "concept proposal" demonstrating our abilities to be CPCCRN leaders.