Impact of insomnia on substance use in people living with HIV

项目总结/摘要 本行政补充，响应PA-18-906：“研究补充，以促进多样性， 健康相关研究（管理支持-不允许进行临床试验）”，将扩展母项目 （R01HL147603，PI-Burel R. Goodin），并为Shameka L博士提供研究和职业发展支持。 科迪，一个终身职位的年轻教员在亚拉巴马大学凯普斯通护理学院， 塔斯卡卢萨，阿拉巴马州。许多报告的共同发生的症状，如睡眠质量差和疼痛存在于 艾滋病毒感染者（PLWH）可能会对生活质量产生负面影响。inflammatory，其特点是 据报道，70%的PLWH存在入睡困难、保持睡眠或两者兼而有之的情况，而 占总人口的35%与失眠类似，超过一半的PLWH可能会经历反复发作的疼痛 症状疼痛是PLWH日益关注的问题，并与睡眠质量差有关。实验室- 研究表明，睡眠剥夺与炎症反应的增加有关， 相同的炎症效应与增加的疼痛敏感性相关。这种多样性的父母补助金 补充的目的是研究失眠对疼痛和疼痛相关炎症的影响。 PLWH中的过程。物质使用是失眠可能促进疼痛的另一种机制， 对PLWH的炎症作用。近50%的艾滋病毒携带者报告了目前或过去的药物或酒精障碍史。 物质使用与全身炎症增加有关，在PLWH中，这些影响可能更多 并加速疾病的发展。探索失眠对疼痛和疼痛相关的影响 感染艾滋病毒的物质使用者的炎症过程将增强母体研究，并代表了一种创新的 为初级教员提供培训机会。补充的科学目标是：（1）增加父母 招募PLWH和物质使用的研究，（2）检查失眠对疼痛的影响， HIV+物质使用者的疼痛相关过程不同，（3）确定物质使用和失眠的相互作用 在预测增加的疼痛敏感性和升高的炎性生物标志物水平（即，IL-6、TNF-α和C- 反应蛋白）。这份增刊也为科迪博士这个前途无量的大三学生制定了三个职业发展目标 教师在护理，艾滋病毒和老龄化，睡眠质量的背景：（1）获得临床和 睡眠医学的转化研究培训;（2）提高她对PLWH睡眠质量差的认识， 物质使用对生活质量决定因素的影响;（3）学习如何建立多学科研究 团队，出席国家和国际会议，开发第一作者同行评审的手稿， 为一名早期职业调查员制定一份有竞争力的建议书R 01。

Project Summary/Abstract This administrative supplement, in response to PA-18-906: “Research Supplements to Promote Diversity in Health-Related Research (Admin Supp – Clinical Trial Not Allowed)”, will expand the parent project (R01HL147603, PI-Burel R. Goodin), and provide research and career development support for Dr. Shameka L. Cody, a tenure track junior faculty member at The University of Alabama Capstone College of Nursing in Tuscaloosa, AL. Numerous reports of co-occurring symptoms such as poor sleep quality and pain exist among people living with HIV (PLWH) which can negatively impact quality of life. Insomnia, which is characterized by difficulty falling asleep, staying asleep or both, has been reported among 70% of PLWH compared to less than 35% of the general population. Similar to insomnia, over half of PLWH are likely to experience recurring pain symptoms. Pain is a growing concern for PLWH and has been associated with poor sleep quality. Laboratory- based studies have shown that sleep deprivation is associated with increased inflammatory effects, and these same inflammatory effects are associated with increased pain sensitivity. The parent grant for this Diversity Supplement has been designed to examine the impact of insomnia on pain and pain-related inflammatory processes in PLWH. Substance use is another mechanism by which insomnia may promote pain and inflammatory effects in PLWH. Nearly 50% of PLWH report current or past histories of drug or alcohol disorders. Substance use is associated with increased systematic inflammation, and in PLWH, these effects may be more profound and hasten disease progression. Exploring the impact of insomnia on pain and pain-related inflammatory processes in substance users with HIV will enhance the parent study, and represents an innovative training opportunity for a junior faculty. The scientific goals of the supplement are to: (1) augment the parent study with recruitment of PLWH and substance use, (2) examine whether the impact of insomnia on pain and pain-related processes differ by HIV+ substance users, (3) identify the interaction of substance use and insomnia in predicting increased pain sensitivity and elevated inflammatory biomarker levels (i.e., IL-6, TNF-α, and C- reactive protein). This supplement also has three career development goals for Dr. Cody, a promising junior faculty with a background in Nursing, HIV and aging, and sleep quality: (1) acquire expertise in clinical and translational research training in Sleep Medicine; (2) advance her knowledge of poor sleep quality in PLWH and its effects with substance use on quality of life determinants; (3) learn how to build multidisciplinary research teams, present at national and international conferences, develop first-author peer-reviewed manuscripts, and develop a competitive proposal for an early-career investigator R01.