Examining person and event level predictors of simultaneous alcohol and marijuana use via mixed methods

项目摘要 这个F31研究和培训奖将使候选人能够发展为公共卫生研究人员， 先进的方法和统计技术，以审查个人和事件层面的实质性决定因素 使用.酒精和大麻是年轻人最常用的两种物质， 使用这两种物质的人同时使用它们（在同一场合，因此它们的效果重叠）。 与单独使用酒精或大麻相比，同时使用酒精和大麻（SAM）与 更频繁和更强烈的酒精使用，以及更多和严重的酒精相关后果。 鉴于SAM使用的高流行率和不良影响，确定SAM使用的近端预测因素 在青年人中开展宣传对于宣传预防和干预工作十分重要。综合行为 模型（IBM）通过强调重要的心理社会（态度， 规范）和上下文（例如，社会背景）预测。本F31中提出的研究的总体目标 描述事件水平SAM使用的特征，并检查IBM告知的重度饮酒中SAM使用的途径 年轻人，使用混合方法。第一，定性方法（20-28名重 饮酒的年轻成年SAM使用者）将用于（a）阐明SAM使用的地形和近端前因 和（B）告知事件级评估决策， 研究离散物质使用事件的EMA评估方案。随后，这款F31应用将 以NIAAA资助的R 01 EMA研究（R 01 AA 027495）为基础，研究高强度饮酒和酒精 在年轻人中引发停电。候选人将在R 01的一个面板中添加SAM特定的措施 评估和随后的30天EMA爆发。使用前100名经常进行SAM的参与者 使用，考生将分析SAM使用的个人和事件水平预测因素的直接影响，并检查 社会心理预测因素与SAM使用之间关联的事件水平中介者和调节者， 年轻的酗酒者。候选人将与一个高技能的导师团队（詹妮弗梅里尔博士， 布朗大学酒精和成瘾研究中心的克里斯蒂娜杰克逊和凯特凯莉）建立了四个 与本研究议程相关的专业领域：（1）年轻人使用SAM的内容领域知识; (2)定性方法和分析;（3）EMA方法;（4）EMA数据分析。F31计划 了解SAM使用的决定因素将有助于确定处于高风险的年轻人的干预目标。 物质滥用和相关后果的风险，并将定位候选人，使重要的 对物质使用研究领域的贡献。

PROJECT SUMMARY This F31 research and training award will enable the candidate to develop as a public health researcher using advanced methodology and statistical techniques to examine person- and event-level determinants of substance use. Alcohol and marijuana are two of the most commonly used substances among young adults, and most individuals who use both substances use them simultaneously (in the same occasion so their effects overlap). Simultaneous alcohol and marijuana (SAM) use, compared to alcohol or marijuana use alone, is associated with more frequent and intense alcohol use, and a greater number and severity of alcohol-related consequences. Given the high prevalence and adverse effects of SAM use, identification of proximal predictors of SAM use among young adults is important for informing prevention and intervention efforts. The Integrated Behavioral Model (IBM) provides a framework for understanding SAM use by highlighting important psychosocial (attitudes, norms) and contextual (e.g., social context) predictors. The overall aims of the research proposed in this F31 are to characterize event-level SAM use and examine IBM-informed pathways of SAM use among heavy drinking young adults, using a mixed methods approach. First, qualitative methods (individual interviews with 20-28 heavy drinking young adult SAM users) will be used to (a) elucidate topography and proximal antecedents of SAM use among young adult heavy drinkers and (b) inform event-level assessment decisions for an ecological momentary assessment (EMA) protocol for studying discrete substance use events. Subsequently, this F31 application will build upon an NIAAA-funded R01 EMA study (R01AA027495) examining high intensity drinking and alcohol induced blackouts among young adults. The candidate will add SAM-specific measures to one of the R01’s panel assessments and subsequent 30 day EMA burst. Using the first 100 participants who engage in frequent SAM use, the candidate will analyze direct effects of person- and event-level predictors of SAM use, and examine event-level mediators and moderators of the association between psychosocial predictors and SAM use among young adult heavy drinkers. The candidate will work with a highly skilled mentorship team (Drs. Jennifer Merrill, Kristina Jackson, and Kate Carey) at Brown University’s Center for Alcohol and Addiction Studies to build four areas of expertise relevant to this research agenda: (1) content area knowledge of SAM use among young adults; (2) qualitative methods and analysis; (3) EMA methods; and (4) analysis of EMA data. This F31 proposal to understand determinants of SAM use will help to identify intervention targets for young adults who are at high risk for substance misuse and related consequences, and will position the candidate to make important contributions to the field of substance use research.