New Nanoparticle Strategies for Efficient Delivery and Controlled Release into the Brain

治疗神经退行性疾病的一个关键挑战是跨越血脑屏障(BBB)的药物输送。该项目将在系统研究血脑屏障渗透机制和近红外药物控制释放策略的基础上，开发先进的血脑屏障“纳米航天器”。这些递送系统可能有助于脑部疾病的诊断和按需将药物释放到大脑中的病变细胞，为治疗脑部疾病提供了一种全新的局部疗法的潜力。

A key challenge for treating neurodegenerative diseases is delivery of drugs across the blood–brain barrier (BBB). This project will develop advanced BBB “nanoshuttles” based upon systematic investigation of BBB penetration mechanisms and near-infrared drug controlled release strategy. These delivery systems may facilitate diagnosis of brain diseases and on-demand release of drug cargos to diseased cells in the brain, offering the potential of a brand new localised therapy for brain diseases.