Factors impacting locomotor learning following stroke

项目总结/摘要 中风往往导致许多身体损害，限制功能性活动，使其成为主要原因 美国长期残疾人。康复专业人员和中风幸存者的主要目标 就是提高行走能力。尽管为改善行走做出了重大努力，但许多中风幸存者无法 中风后能独立行走这部分是由于中风幸存者如何应对 康复干预。因为运动学习是有效康复干预的基础， 中风后运动学习的变异性是这种变异性的一个来源。到目前为止，几乎没有 关于导致这种变化的因素的信息，如果定制中风后的挑战 康复干预。以前的研究已经检查了人口统计信息和感觉运动 损伤作为解释中风后运动学习变异性的潜在因素;然而，这些因素 还没有发现可以解释变异性的显著部分。在健康的成年人中，认知被发现 解释学习上肢任务的变异性，但这还没有在行走或中风后进行检查， 认知缺陷是常见的。因此，本提案的总体目标是确定 认知和运动学习之间的联系在目标1中，我们将研究 中风幸存者学习新的行走模式和流体认知。在目标2中，我们将研究 中风幸存者记忆新的行走模式（即保持）和流体认知之间的关系。的 该项目的结果将解决我们对中风后运动学习理解的关键差距， 我们可以更好地定制康复干预措施，以优化中风后的结果。此外，这一提议 工作是实现这一奖学金申请人长期目标的第一步，这是成为一个 成功的临床科学家专注于开发个性化的康复干预措施， 中风后的功能恢复通过在经验丰富的 导师在一个强大的研究环境中，申请人将获得成功所需的培训， 完成计划中的工作，发展成为一名多产的科学家，并实现她的长期职业目标。

PROJECT SUMMARY/ABSTRACT Stroke often results in numerous physical impairments that limit functional mobility, making it the leading cause of long-term disability in the United States. A primary goal for rehabilitation professionals and stroke survivors is to improve walking abilities. Despite significant efforts to improve walking, many stroke survivors are unable to walk independently after their stroke. This is in part due to variability in how stroke survivors respond to rehabilitation interventions. Because motor learning is the foundation for effective rehabilitation interventions, variability in locomotor learning after stroke is one source of this variability. To date, there is almost no information on factors that account for this variability, making if challenging to customize post stroke rehabilitation interventions. Previous research has examined demographic information and sensorimotor impairments as potential factors to explain variability in locomotor learning after stroke; however, these factors have not been found to explain a significant portion of variability. In healthy adults, cognition has been found to explain variability in learning upper extremity tasks, but this has not been examined in walking or after stroke, where cognitive deficits are common. Thus, the overall goal of this proposal is to determine the relationship between cognition and locomotor learning after stroke. In Aim 1 we will examine the relationship between learning a new walking pattern and fluid cognition in stroke survivors. In Aim 2, we will examine the relationship between remembering the new walking pattern (i.e. retention) and fluid cognition in stroke survivors. The results of this project will address critical gaps in our understanding of locomotor learning after stroke and allow us to better customize rehabilitation interventions to optimize post stroke outcomes. Additionally, this proposed work serves as a first step towards the long-term goal of this fellowship applicant, which is to become a successful clinician scientist focused on developing personalized rehabilitation interventions that optimize functional recovery after stroke. By completing this fellowship proposal under the guidance of experienced mentors in a strong research environment, the applicant will receive the training needed to successfully complete the proposed work, to develop into a productive scientist, and to achieve her long term career goals.