High School Student NeuroResearch Program (HSNRP)

摘要 亚利桑那大学高中生神经研究项目(HSNRP) 引进、培训和培养越来越多有才华的亚利桑那州高中 学生，由精选的进步本科生扩大，包括大多数 在基础、翻译和临床研究中未充分代表弱势少数群体 正常和异常的神经系统、神经紊乱和中风，也鼓励 追求先进的研究经验，并从事与健康/医疗/科学相关的职业。 我们正在利用强大的基础设施、有效的招聘战略、高水平的 学生/教师导师的参与、团队精神和优秀的实习生工作效率 长期由联邦政府资助的多学科/多专业的贫困高中 学生、本科生和医学生的暑期研究项目和全年 丰富活动，为本专业神经研究(NR)的培训模式注入活力 程序。14-16全日制8-12周暑期高中和4-6名本科实习生 在接下来的5年里，每年都将提供更多的严密指导的NR菜单 经验；为了在管道中保留，将随后选择HSNRP学员 再次被任命为更高级的NR。通过互动，这些学员将融入到 一个创新的、国际公认的以探究性为基础的医学无知夏季研究所 (SIMI)，它交织着生物医学的已知和未知(“我们知道我们不知道的， 不知道我们不知道，并认为我们知道但不知道“)与特色的NR主题和导师 “故事”，并通过常年定期的丰富活动保持势头。西米 强调“翻译、翻译和科学提问”，并包括一个简短的介绍 病理生物学和医学语言、专题研讨会、实验室/领导力/ 多媒体技能研讨会和实践、临床相关性、社交网络和职业 建议。一个独特的虚拟临床研究中心/问卷室形成一部手机 无障碍-培训和国内/国际网络的核心平台。在基本范围内 以及临床科室和专业卓越中心的强化神经科学 强调并由精力充沛、经验丰富的多学科HSNRP领导团队监督 和咨询委员会，学生研究将涵盖交叉主题和体内、 包括帕金森在内的神经生物学/疾病的体外、原位、硅胶和建模方法， 阿尔茨海默病，尼曼-皮克C病，肌萎缩侧索硬化症，癫痫，艾滋病毒脑病，头部创伤， 脑积水，肌营养不良，疼痛/成瘾药理学，分子精神病学， 认知，脑发育，脑图谱，衰老，智力低下，血脑 屏障/神经保护，神经成像，神经基因组学/蛋白质组学，神经工程，深度 脑刺激、脑瘤、脑血管疾病、中风、神经健康差异，以及 康复。基于我们约29年的跟踪记录，并建立了对各种大型 亚利桑那州弱势学生群体在615名受过SIMI培训的高中生中的反映 到目前为止与许多基础/临床神经研究(本科生/研究生/ 专业学位/生物医学-健康职业)，我们预计HSNRP将继续 培养由多样化和好奇心的研究人员、医生和其他健康人员组成的不断扩大的网络 专业人员；为神经研究管道和企业做出贡献；并改进 通过社区参与提高“神经健康”素养。持续的短期和长期 评价包括调查、数据库登记、“好奇心”量表、短期和长期跟踪、 和职业组合，以记录培训模式的有效性和可持续性，促进 多样性，以及国家/国际网络。

ABSTRACT The University of Arizona (UA) High School Student NeuroResearch Program (HSNRP) introduces, trains, and nurtures a growing pipeline of diverse talented Arizona high school students, expanded by select progressing undergraduates, including a majority of underrepresented disadvantaged minorities in basic, translational, and clinical research on the normal and abnormal nervous system, neurological disorders, and stroke, and also encourages pursuit of advanced research experiences and fulfilling health/medical/science-related careers. We are leveraging the strong infrastructure, effective recruitment strategies, high level of student/faculty mentor participation, esprit-de-corps, and outstanding trainee productivity of our long-standing federally funded multidisciplinary/multispecialty disadvantaged high school student, undergraduate, and medical student summer research programs and year-round enrichment activities to energize the training model for this specialized NeuroResearch (NR) program. Fourteen-16 full-time 8-12 week summer high school and 4-6 undergraduate trainees annually for the next 5 years will be offered an expanding menu of closely mentored NR experiences; for retention in the pipeline, select HSNRP trainees will be subsequently reappointed for more advanced NR. Interacting together, these trainees will be integrated into an innovative, internationally recognized inquiry-based Summer Institute on Medical Ignorance (SIMI) which interweaves biomedical Knowns and Unknowns ("what we know we don't know, don't know we don't know, and think we know but don't") with featured NR topics and mentor "stories" and sustains the momentum by periodic enrichment activities year-round. SIMI emphasizes "translating translation and scientific questioning" and includes a brief Introduction to Pathobiology and the language of medicine, topical seminars, laboratory/leadership/ multimedia skill workshops and practicums, clinical correlations, social networking, and career advising. A unique Virtual Clinical Research Center/Questionarium forms a mobile phone accessible-centerpiece platform for training and national/international networking. Within basic and clinical departments and specialized Centers of Excellence with enhanced Neuroscience emphasis and overseen by an energetic experienced multidiscplinary HSNRP Leadership Team and Advisory Committee, student research will encompass cross-cutting themes and in vivo, in vitro, in situ, in silico, and modeling approaches to neurobiology/disorders including Parkinson, Alzheimer, Niemann-Pick C diseases, ALS, epilepsy, HIV encephalopathy, head trauma, hydrocephalus, muscular dystrophy, pain/addiction pharmacology, molecular psychiatry, cognition, brain development, brain mapping, senescence, mental retardation, blood-brain barrier/neuroprotection, neuroimaging, neuro-genomics/proteomics, neuroengineering, deep brain stimulation, brain tumors, cerebrovascular disease, stroke, neurohealth disparities, and rehabilitation. Based on our ~29-year track record and established access to large diverse pools of disadvantaged Arizona students reflected in 615 SIMI-trained high school students followed to date with many in the basic/clinical NeuroResearch (undergraduate/graduate/ professional degree/biomedical-health career) pipeline, we expect HSNRP to continue to cultivate an expanding network of diverse and curious researchers, physicians and other health professionals; contribute to the NeuroResearch pipeline and enterprise; and improve "neurohealth" literacy through community engagement. Ongoing short-term and long-term evaluation includes surveys, database registry, "curiosity" scales, short- and long-term followup, and career portfolios to document efficacy and sustainability of the training model, promote diversity, and national/international networking.