Changing lives, changing brains: How modern family and work life influences ADRD risks

阿尔茨海默病和相关痴呆症(ADRD)的患病率预计到2020年将增加两倍 2050年。目前，对ADRD尚无有效的治疗方法。通过行为预防 因此，影响ADRD风险的变化是至关重要的，约35%的ADRD风险是 被认为可归因于潜在的可改变因素。当前现代家庭生活的变化 工作和家庭结构可能会对ADRD的风险产生重要影响 可能与ADRD风险有关的个人、生活和环境的多个方面。 然而，工作和家庭作为ADRD风险的途径和调节因素的研究还不够深入。 我们的总体假设是，当代家庭模式和工作生活的变化有助于 与年龄相关的认知改变和ADRD有关。向“现代”家庭结构和工作的转变 挪威的任务发生得相对较早，独特的数据可用性使这些变化成为可能 进行前瞻性研究，以预测美国和其他国家ADRD即将发生的变化。 我们将研究成年后家庭和工作的生命过程的影响和相互作用，以应对风险 老年人的ADRD和认知障碍。这将通过利用异常的 挪威狩猎(Nord-Trondelag Health Study)数据集，正在进行的大量潜在人口 这包括出生于1900-1960年的人群，并结合挪威的国家登记数据。vbl.使用 这些具有人口代表性的队列具有异常详细的健康和社会经济状况 解决这些问题的纵向数据。我们将利用特定的事件来创建 自然实验。我们的研究结果将有助于识别生命过程中的“敏感期” 它们如何调节认知功能减退和ADRD的遗传风险。

The prevalence of Alzheimer's disease and related dementias (ADRD) is projected to triple by 2050. Currently, there is no known effective treatment for ADRD. Prevention through behavioral changes affecting ADRD risk is therefore of utmost importance, and about 35% of ADRD risk is thought to be attributable to potentially modifiable factors. Current changes in modern family life and work are likely to have important effects on the risk of ADRD, as the work and family structure multiple aspects of individuals lives and environments that are likely to be related to ADRD risks. Yet, work and family trajectories as pathways and moderators of ADRD risk are understudied. Our overall hypothesis is that contemporary changes in family patterns and work lives contribute to age related changes in cognition and ADRD. A shift to “modern” family structures and work tasks have occurred relatively early in Norway, and unique data availability allows these changes to be studied prospectively to predict coming changes in ADRD in the US and other countries. We will study life-course effects of and interactions between family and work in adulthood for risk of ADRD and cognitive impairment in older adults. This will be done by exploiting the exceptional Norwegian HUNT (Nord-Trondelag Health Study) dataset, a large ongoing prospective population that includes cohorts born 1900 – 1960, combined with Norwegian national registry data. Using these population-representative cohorts have exceptionally detailed health and socioeconomic longitudinal data to address these issues. We will take advantage of specific events that create natural experiments. Our results will help to identify “sensitive periods” over the life course and how they mediate genetic risks of cognitive decline and ADRD.