Real-Time L-Dopa Monitoring for Improved Management of Parkinson Disease

项目摘要 左旋多巴治疗的给药是高度个体化的，必须根据临床试验的要求给药。 控制症状，这是因人而异的;因此，没有“标准剂量”的左旋多巴。的 该项目的长期目标是开发一种可穿戴的微针传感器，用于连续实时 监测左旋多巴，以确定适当的左旋多巴给药方案，并改善 帕金森病的治疗这种连续的L-多巴监测能力将构成一种 通过允许PD患者和医生更好地管理疾病来实现范式转变。就像一个封闭的- 环路葡萄糖监测器-胰岛素泵系统，从这项研究中收集的见解可能导致 开发了一种定量的左旋多巴泵，通过考虑 血液中左旋多巴的含量这项研究之所以重要，是因为它有可能 通过更好地了解不同疾病症状波动来改善公共卫生 阶段及其对如何改善疾病管理的科学知识的贡献。

Project Summary The administration of L-Dopa therapies is highly individualized and must be dosed in accordance with the control of symptoms, which vary among individuals; hence, there is no “standard dose” of L-Dopa. The long-term goal of this project is to develop a wearable microneedle sensor for continuous real-time monitoring of L-Dopa toward identifying the proper L-Dopa dosing regimen and improving the management of Parkinson's disease. Such continuous L-Dopa monitoring capability would constitute a paradigm shift by allowing PD patients and physicians to better manage the disease. As with a closed- loop glucose monitor-insulin pump system, the insight gathered from this research could lead towards the development of a metered L-Dopa pump, ensuring accurate L-Dopa administration by accounting for circulating blood levels of L-Dopa. The proposed research is significant because of its potential to improve public health through improved understanding of symptom fluctuations at different disease stages and its contribution to scientific knowledge about how to improve the disease management.