UNC post-doctoral training program in comparative effectiveness research

描述（由申请人提供）：位于查佩尔山的北卡罗来纳州大学的塞西尔G Sheps中心很高兴提交此申请，以启动比较有效性研究（CER）的T-32博士后培训计划。这个额外的计划将建立在谢普斯中心和AHRQ在卫生服务研究的博士前和博士后培训方面20多年的合作基础上。该计划将由蒂姆凯里博士，目前的计划和谢普斯中心主任。CER是一个不断发展的跨学科活动，从临床医学，流行病学，卫生政策和药学的学科。我们的社会迫切需要评估诊断检测和治疗的最佳战略，以改善我们公民的保健。CER的组成部分包括通过系统性综述评价当前证据;观察性研究和分析，如药物流行病学和建模研究;开展大型有效性试验;以及传播和实施活动。我们的13名核心教师来自四个健康科学学院（医学，公共卫生，牙科和药学）和七个部门。CENTRAL目前在CER方面有大量活动，包括通过循证实践（EPC）网络与AHRQ签订的系统性综述主任务订单合同;通过DEclDE网络进行的观察性研究;广泛的基于实践的研究网络（PBRN）活动，包括与AHRQ签订的主任务订单合同;大型随机试验;以及传播研究。它也是NIH CTSA网站。预计研究员将参与正在进行的内容和方法研究。教学工作将包括通过UNC-CH的MPH或MS临床医生计划授予学位的计划。博士将参加选定的课程，重点是CER方法，以及校园内的其他地方。研究员将参加每周一次的综合研讨会，以及每周一次的CER方法研讨会。我们请求提供资金，以支助五名研究员，每人两年，其中两名开始在第一年，三名开始在第二年。我们还获得了四个外部网站的同意，这些网站的研究与UNCCH相辅相成：消费者联盟;达特茅斯卫生政策研究所;达勒姆VA HSR&D中心;以及美国放射成像研究网络学院（ACRIN）。 相关性：最近由LOM、联邦协调理事会、ARRA立法和拟议的卫生改革立法提出的倡议大大增加了比较有效性研究活动的数量及其潜在的政策影响。因此，国家正经历着对更多研究人员的巨大需求，以满足系统性综述、观察性研究、有效性试验和研究传播等领域的需求。能够迅速应用的技能尤其重要，相关的重点是加强比较有效性研究所涉及的方法。

DESCRIPTION (provided by the applicant): The Cecil G Sheps Center at the University of North Carolina at Chapel Hill (UNC) is pleased to submit this application to initiate a T-32 postdoctoral training program in comparative effectiveness research (CER). This additional program will build on over 20 years of collaboration between the Sheps Center and AHRQ in pre- and postdoctoral training in health services research. The program will be directed by Dr. Tim Carey, director of the current program and of the Sheps Center. CER is a growing interdisciplinary activity, drawing from the disciplines of clinical medicine, epidemiology, health policy, and pharmacy. Our society has an urgent need to evaluate the best strategies of diagnostic testing and treatment so as to improve health care for our citizens. The components of CER include evaluation of current evidence through systematic reviews; observational studies and analyses such as pharmacoepidemiology and modeling research; conduct of large effectiveness trials; and dissemination and implementation activities. Our 13 core faculty are drawn from four health science schools (medicine, public health, dentistry, and pharmacy) and seven departments. UNC has substantial current activities in CER, including master task order contracts with AHRQ for systematic reviews through the Evidence-based Practice (EPC) network; observational studies through the DEclDE network; extensive practice-based research network (PBRN) activities including a master task-order contract with AHRQ; large randomized trials; and dissemination research. UNC is also an NIH CTSA site. Fellows will be expected to participate in ongoing content and methods research. Didactic work will include degree granting programs through UNC-CH's MPH or MS program for clinicians. PhDs will enroll in selected courses focusing on CER methods, as well as elsewhere on campus. Fellows will participate in a weekly integrative seminar, as well as a weekly seminar on CER methods. We are requesting funds to support five fellows for two years each, two to begin in Year 1 and three to begin in Year 2. We have also obtained agreement from four external sites with research complementary to UNCCH: Consumer's Union; the Dartmouth Institute for Health Policy; the Durham VA HSR&D Center; and the American College of Radiology Imaging Research Network (ACRIN). RELEVANCE: Recent initiatives by the lOM, the Federal Coordinating Council, ARRA legislation, and proposed health reform legislation have substantially increased the amount of comparative effectiveness research activity and its potential policy impact. As a result, the nation is experiencing a great need for more researchers to meet the demand in areas of systematic review, observational studies, effectiveness trials, and research dissemination. Skills that can be rapidly applied are especially important, and a related focus is enhancement of the methods involved in comparative effectiveness research.