2/2 Partnerships to Enhance Alcohol Research Across NCCU and UNC (PEAR-NC)

2/2 加强 NCCU 和 UNC 酒精研究的合作伙伴关系 (PEAR-NC)

• 批准号: 10705685
• 负责人: FULTON T CREWS
• 金额: $ 31.1万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705685
• 关键词: ARHGEF5 gene; Address; Adolescent; Adult; African American; African American population; African American student; Alcohol abuse; Alcohols; Area; Award; Behavioral; Brain; Collaborations; Core Facility; Course Content; Data; Education; Educational Curriculum; Educational process of instructing; Endowment; Environment; Ethanol toxicity; Faculty; Fetal Alcohol Spectrum Disorder; Funding; Future; Goals; Grant; Health Professional; Historically Black Colleges and Universities; Inflammation; Infrastructure; Institution; Internships; Joints; Knowledge; Laboratories; Laboratory Research; Leadership; Learning; Manuscripts; Medical; Medical Libraries; Mentors; Minority; Molecular; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Neuroimmune; North Carolina; Pathology; Preparation; Process; Productivity; Publications; Research; Research Personnel; Research Project Grants; Research Technics; Resource Sharing; Resources; Scholarship; Series; Severities; Structure; Students; Techniques; Tissues; Toxic effect; Training; U-Series Cooperative Agreements; Underrepresented Minority; United States National Institutes of Health; Universities; Work; alcohol exposure; alcohol research; alcohol use disorder; carcinogenesis; career; cellular pathology; expectation; experience; experimental study; faculty mentor; fetal; graduate student; health disparity; improved; interest; laboratory development; laboratory experience; lectures; malignant breast neoplasm; mammary; medical schools; meetings; minority investigator; neuropathology; neurotoxicity; post-doctoral training; programs; recruit; research and development; response; role model; skills; stem cells; success; summer internship; synergism; undergraduate student; underrepresented minority student; university student; virology

This is an application for a cooperative agreement (U54), “Partnerships to Enhance Alcohol Research across NCCU and UNC (PEAR-NC),” between faculties of North Carolina Central University (NCCU), a Historically Black College or University, and the Bowles Center for Alcohol Studies (BCAS) at the University of North Carolina (UNC) School of Medicine. This proposal represents a true collaborative effort between the NCCU and UNC faculty with both groups contributing significant effort and being essential to the success of this Alcohol and Health Disparities program. Within this proposal, an NCCU Administrative Core and three Research Components will integrate with the UNC-BCAS Administrative Research Components, as well as other activities at the Bowles Center for Alcohol Studies. The UNC NIAAA Alcohol Research Center (ARC) and BCAS have many faculty studying mechanisms of alcohol pathology across the spectrum of behavioral, tissue, and cellular pathologies that occur with alcohol exposure. This proposal will focus on cellular pathologies that allow collaborative research partnerships on common areas of interest between UNC and NCCU faculty. These partnerships open UNC research laboratories, core facilities, and medical libraries to NCCU faculty, improving opportunities for developing productive research laboratories at NCCU. In addition, due to recent NCCU NIAAA R awards, large numbers of NCCU students will continue to become involved in research on mechanisms of alcohol pathology, providing education on African American alcohol-related health disparities which are due to increased morbidity to alcohol-related pathologies and not increased alcohol use disorder. The objective of this U54 partnership is to investigate molecular mechanisms of alcohol-induced cellular pathology. This proposal includes three NCCU research projects, involving six NCCU faculty, that will investigate the molecular mechanisms of fetal alcohol pathology, alcohol-induced mammary stem cell toxicity, and neuroimmune responses in adolescent and adult brain. A second objective is to provide research experiences and scholarly education on alcohol pathology for NCCU students. The educational efforts in this proposal will involve NCCU undergraduate and graduate students through the BCAS seminar series, through training in UNC laboratories and research development and mentor meetings, attendance and presentation of data at the annual RSA meeting, an alcohol seminar series hosted by NCCU, new course curricula on alcohol pathology developed with a focus on health disparities, as well as specific undergraduate student summer internships for NCCU students to study and learn about alcohol pathology and health disparities within laboratories in both institutions. Ultimately, this proposal will conduct, promote, support, and mentor research into mechanisms of alcohol pathology, creating an active and successful alcohol research program within NCCU that synergizes with UNC to advance education and discoveries.

这是一个合作协议（U 54）的应用程序，“合作伙伴关系，以加强酒精研究， NCCU和PEAR-NC（PEAR-NC），”北卡罗来纳州中央大学（NCCU）的院系之间，一个历史上 布莱克学院或大学，以及北方大学的鲍尔斯酒精研究中心（BCAS） 卡罗莱纳（UNC）医学院。该提案代表了NCCU之间真正的合作努力 这两个群体都做出了重大努力，对这一项目的成功至关重要。 酒精和健康差异计划。在这一建议中，一个NCCU行政核心和三个 研究部门将与UNC-BCAS行政研究部门合并，以及 鲍尔斯酒精研究中心（Bowles Center for Alcohol Studies）美国酒精研究中心（ARC） BCAS有许多教师研究酒精病理学的机制，包括行为，组织， 以及酒精暴露引起的细胞病变。该提案将重点关注细胞病理学， 允许合作研究伙伴关系的共同感兴趣的领域之间的共同利益，北卡罗来纳大学和NCCU教师。 这些合作伙伴关系向NCCU教师开放了生物医学研究实验室，核心设施和医学图书馆， 改善机会，发展生产研究实验室在NCCU。此外，由于近期 NCCU NIAAA R奖，大量的NCCU学生将继续参与研究 酒精病理学机制，提供关于非裔美国人酒精相关健康差异的教育 这是由于酒精相关疾病的发病率增加，而不是酒精使用障碍增加。 U 54合作的目的是研究酒精诱导的细胞凋亡的分子机制。 病理这项提案包括三个NCCU研究项目，涉及六个NCCU教师，将 研究胎儿酒精病理学的分子机制，酒精诱导的乳腺干细胞毒性， 以及青少年和成人大脑中的神经免疫反应。第二个目标是提供研究 为政大学生提供酒精病理学的学术教育。在这方面的教育努力 建议将涉及NCCU本科生和研究生通过BCAS研讨会系列，通过 在实验室和研究开发方面的培训，以及导师会议，出席和介绍 数据在年度RSA会议上，由NCCU主办的酒精研讨会系列，关于酒精的新课程 病理学的发展重点是健康差异，以及特定的本科生夏季 NCCU学生的实习研究和了解酒精病理学和健康的差距， 两个实验室。最终，该提案将指导、促进、支持和指导研究 酒精病理学的机制，创建一个积极和成功的酒精研究计划， NCCU与EMBA协同推进教育和发现。