2/2 Partnerships to Enhance Alcohol Research Across NCCU and UNC (PEAR-NC)

这是一份合作协议(U54)的申请书，该协议名为“加强酒精研究的伙伴关系” NCCU和UNC(PEAR-NC)，北卡罗来纳中央大学(NCCU)的教职员工之间，历史上 布莱克学院或大学，以及北方大学鲍尔斯酒精研究中心(BCAS) 北卡罗来纳大学医学院。这项提议代表了NCCU与NCCU之间真正的合作努力 和北卡罗来纳大学的教职员工，这两个群体都做出了巨大的努力，对这次活动的成功至关重要 酒精与健康差异计划。在这项提案中，NCCU的一个行政核心和三个 研究部分将与北卡罗来纳大学-BCAS行政研究部分以及 鲍尔斯酒精研究中心的其他活动。北卡罗来纳大学NIAAA酒精研究中心(ARC)和 BCAS有许多教员研究酒精病理的机制，涉及行为、组织、 以及酒精暴露引起的细胞病变。这项建议将重点放在细胞病理学上， 允许北卡罗来纳大学和北卡罗来纳大学教职员工在共同感兴趣的领域建立合作研究伙伴关系。 这些伙伴关系向北卡罗来纳大学的教职员工开放北卡罗来纳大学的研究实验室、核心设施和医学图书馆， 改善NCCU发展生产性研究实验室的机会。此外，由于最近 NCCU NIAAA R奖，大量NCCU学生将继续参与关于 酒精病理机制，提供关于非裔美国人与酒精相关的健康差异的教育 这是由于酒精相关病理的发病率增加，而不是酒精使用障碍的增加。 这个U54合作伙伴的目标是研究酒精诱导细胞的分子机制 病理学。这项提案包括三个NCCU研究项目，涉及NCCU的六名教职员工，这些项目将 探讨胎儿酒精病理、酒精致乳腺干细胞毒性的分子机制 以及青少年和成人大脑中的神经免疫反应。第二个目标是提供研究 国立师范大学学生酒精病理学的经验与学术教育。在这方面的教育努力 提案将通过BCAS系列研讨会让NCCU本科生和研究生参与，通过 在北卡罗来纳大学实验室进行培训以及研究开发和导师会议，出席并介绍 在NCCU主办的酒精研讨会系列RSA年会上的数据，关于酒精的新课程课程 病理学发展的重点是健康差异，以及特定的本科生暑期 为NCCU学生提供的实习机会，以学习和了解酒精病理和健康差距 这两个机构的实验室。最终，这项提案将进行、促进、支持和指导研究 研究酒精病理机制，创建一个积极而成功的酒精研究计划 NCCU与北卡罗来纳大学协同推进教育和发现。

This is an application for a cooperative agreement (U54), “Partnerships to Enhance Alcohol Research across NCCU and UNC (PEAR-NC),” between faculties of North Carolina Central University (NCCU), a Historically Black College or University, and the Bowles Center for Alcohol Studies (BCAS) at the University of North Carolina (UNC) School of Medicine. This proposal represents a true collaborative effort between the NCCU and UNC faculty with both groups contributing significant effort and being essential to the success of this Alcohol and Health Disparities program. Within this proposal, an NCCU Administrative Core and three Research Components will integrate with the UNC-BCAS Administrative Research Components, as well as other activities at the Bowles Center for Alcohol Studies. The UNC NIAAA Alcohol Research Center (ARC) and BCAS have many faculty studying mechanisms of alcohol pathology across the spectrum of behavioral, tissue, and cellular pathologies that occur with alcohol exposure. This proposal will focus on cellular pathologies that allow collaborative research partnerships on common areas of interest between UNC and NCCU faculty. These partnerships open UNC research laboratories, core facilities, and medical libraries to NCCU faculty, improving opportunities for developing productive research laboratories at NCCU. In addition, due to recent NCCU NIAAA R awards, large numbers of NCCU students will continue to become involved in research on mechanisms of alcohol pathology, providing education on African American alcohol-related health disparities which are due to increased morbidity to alcohol-related pathologies and not increased alcohol use disorder. The objective of this U54 partnership is to investigate molecular mechanisms of alcohol-induced cellular pathology. This proposal includes three NCCU research projects, involving six NCCU faculty, that will investigate the molecular mechanisms of fetal alcohol pathology, alcohol-induced mammary stem cell toxicity, and neuroimmune responses in adolescent and adult brain. A second objective is to provide research experiences and scholarly education on alcohol pathology for NCCU students. The educational efforts in this proposal will involve NCCU undergraduate and graduate students through the BCAS seminar series, through training in UNC laboratories and research development and mentor meetings, attendance and presentation of data at the annual RSA meeting, an alcohol seminar series hosted by NCCU, new course curricula on alcohol pathology developed with a focus on health disparities, as well as specific undergraduate student summer internships for NCCU students to study and learn about alcohol pathology and health disparities within laboratories in both institutions. Ultimately, this proposal will conduct, promote, support, and mentor research into mechanisms of alcohol pathology, creating an active and successful alcohol research program within NCCU that synergizes with UNC to advance education and discoveries.